Li Shuqiong, Liu Yixiang
College of Ocean Food and Biological Engineering, National & Local Joint Engineering Research Center of Deep Processing Technology for Aquatic Products, Jimei University, Xiamen, Fujian, People's Republic of China.
Crit Rev Food Sci Nutr. 2025;65(22):4368-4381. doi: 10.1080/10408398.2024.2387320. Epub 2024 Aug 1.
Dietary flavonoids exhibit a variety of physiological functions in regulating glucose and lipid metabolism, improving cardiovascular function, and enhancing stress resistance. However, poor intestinal absorption limits their health benefits. Previous studies on improving the absorption efficiency of flavonoids have focused on targeted release, enhanced gastrointestinal stability and prolonged retention time in digestive tract. But less attention has been paid to promoting the uptake and transport of flavonoids by intestinal epithelial cells through modulation of transporter protein-mediated pathways. Interestingly, some dietary nutrients have been found to modulate the expression or function of transporter proteins, thereby synergistically or antagonistically affecting flavonoid absorption. Therefore, this paper proposed an innovative regulatory strategy known as the "intestinal transport protein-mediated pathway" to promote intestinal absorption of dietary flavonoids. The flavonoid absorption mechanism in the intestinal epithelium, mediated by intestinal transport proteins, was summarized. The functional differences between the uptake transporter and efflux transporters during flavonoid trans-intestinal cellular transport were discussed. Finally, from the perspective of nutritional synergy promotion of absorption, the feasibility of promoting flavonoid intestinal absorption by regulating the expression/function of transport proteins through dietary nutrients was emphasized. This review provides a new perspective and developing precise dietary nutrient combinations for efficient dietary flavonoid absorption.
膳食类黄酮在调节糖脂代谢、改善心血管功能和增强抗应激能力等方面具有多种生理功能。然而，肠道吸收不佳限制了它们对健康的益处。以往关于提高类黄酮吸收效率的研究主要集中在靶向释放、增强胃肠道稳定性以及延长在消化道中的停留时间。但通过调节转运蛋白介导的途径促进肠道上皮细胞对类黄酮的摄取和转运方面受到的关注较少。有趣的是，已发现一些膳食营养素可调节转运蛋白的表达或功能，从而协同或拮抗地影响类黄酮的吸收。因此，本文提出了一种创新的调控策略，即“肠道转运蛋白介导途径”，以促进膳食类黄酮的肠道吸收。总结了由肠道转运蛋白介导的肠道上皮中类黄酮的吸收机制。讨论了类黄酮跨肠道细胞转运过程中摄取转运体和外排转运体的功能差异。最后，从促进吸收的营养协同作用角度，强调了通过膳食营养素调节转运蛋白表达/功能来促进类黄酮肠道吸收的可行性。本综述为高效膳食类黄酮吸收提供了新的视角并开发精确的膳食营养组合。
