Universiti Sains Malaysia Health Campus, School of Medical Sciences, Department of Chemical Pathology, Kelantan, Malaysia.
Universiti Sains Malaysia Health Campus, School of Medical Sciences, Unit of Biostatistics and Research Methodology, Kelantan, Malaysia.
Med J Malaysia. 2024 Jul;79(4):457-463.
Hyperuricaemia is common in essential hypertension with varying results in different populations. This study sought to ascertain the association between serum uric acid levels and essential hypertension in Hospital Universiti Sains Malaysia (HUSM).
A case-control study design involving 132 subjects (88 subjects of hypertension patients for case group and 44 subjects for control group) aged 18 to 40 years old of both genders was conducted at HUSM primary care clinic and physician clinic from May 2020 to May 2021. Blood samples were collected from each of the case and control subjects and analysed for serum uric acid, urea, creatinine, total cholesterol, triglycerides, LDL and HDL on chemical analyser Architect c8000. The data were analysed by using SPSS Statistics 26.0 version.
The proportion of subjects with hyperuricaemia in the case group was 48.9%. A significant difference in the uric acid levels between the case group (390.64±92.65μmol/L) and control group (352.09±86.07μmol/L), (p<0.05) was observed. There was no significant difference in the serum uric acid mean ± SD based on the duration of hypertension (<5 years and ≥5 years), (p=0.331) and stages of hypertension (p>0.05). In case group, significant correlations were established between uric acid and triglycerides (r=0.255, p<0.05), uric acid and HDL (r= -0.223, p<0.05), uric acid and urea (r=0.299, p<0.05), uric acid and creatinine (r=0.486, p<0.01). No correlation among uric acid and total cholesterol levels (p>0.05), uric acid and LDL (p>0.05). Serum uric acid was a vital variable in developing hypertension (p<0.05) but not when adapted for age and body mass index (BMI) (p>0.05).
Serum uric acid was significantly elevated in essential hypertension. The significant associations were established between uric acid and triglycerides, HDL, urea and creatinine in essential hypertension. Serum uric acid was a vital variable to develop hypertension, but the association was weakened by other co-founders as age and BMI. A large-scale population-based study is required to truly conclude the association between serum uric acid levels and essential hypertension in our population.
高尿酸血症在原发性高血压中很常见，但在不同人群中的结果存在差异。本研究旨在确定血清尿酸水平与马来西亚大学科学医院（HUSM）原发性高血压之间的关系。
采用病例对照研究设计，纳入了 132 名年龄在 18 至 40 岁之间的受试者（88 名高血压患者为病例组，44 名为对照组），于 2020 年 5 月至 2021 年 5 月在 HUSM 初级保健诊所和内科诊所进行。从每个病例组和对照组采集血样，在化学分析仪 Architect c8000 上分析血清尿酸、尿素、肌酐、总胆固醇、甘油三酯、LDL 和 HDL。数据使用 SPSS Statistics 26.0 版本进行分析。
病例组中高尿酸血症的比例为 48.9%。病例组（390.64±92.65μmol/L）与对照组（352.09±86.07μmol/L）的尿酸水平有显著差异（p<0.05）。高血压持续时间（<5 年和≥5 年）（p=0.331）和高血压阶段（p>0.05）对血清尿酸平均值无显著影响。在病例组中，尿酸与甘油三酯（r=0.255，p<0.05）、尿酸与高密度脂蛋白（r=-0.223，p<0.05）、尿酸与尿素（r=0.299，p<0.05）、尿酸与肌酐（r=0.486，p<0.01）之间存在显著相关性。尿酸与总胆固醇水平（p>0.05）、尿酸与 LDL（p>0.05）之间无相关性。血清尿酸是高血压发生的重要变量（p<0.05），但在适应年龄和体重指数（BMI）后则不具有相关性（p>0.05）。
原发性高血压患者的血清尿酸水平显著升高。原发性高血压患者的尿酸与甘油三酯、HDL、尿素和肌酐之间存在显著相关性。血清尿酸是高血压发生的重要变量，但由于年龄和 BMI 等其他共同因素的影响，其相关性减弱。需要进行大规模的人群为基础的研究，才能真正确定我们人群中血清尿酸水平与原发性高血压之间的关系。
