Emokpae Abiodun M, Abdu Aliyu
Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City.
Niger J Physiol Sci. 2013 Jun 30;28(1):41-4.
There is an ongoing debate on the role of serum uric acid as an independent risk factor for hypertension and renal disease. This study determined the serum uric acid levels of Nigerians with essential hypertension and also evaluated the association between serum uric acid levels and blood pressure of these patients. A retrospective case-control study of three hundred and fifty one patients with essential hypertension seen at the hypertension clinic of Aminu Kano Teaching Hospital, Kano between January 2004 and December 2008. The control group comprised of one hundred apparently healthy non hypertensive subjects. The clinical characteristics including blood pressure measurement, serum uric acid, urea, creatinine, lipid profile and glucose were evaluated.The mean systolic and diastolic blood pressures of the male patients were 156mmHg and 101mmHg respectively, while those of the male controls were 120 ± 6.0 and 80 ± 5 respectively. The mean serum uric acid, fasting blood glucose, urea and creatinine were 483umol/L, 5.7mmol/L,6.61mmol/L, 93umol/l respectively compared to those of the male controls which were 326 ±10μmol/l, 5.0± 0.5mmol/l, 4.2± 0.12mmol/l, 5.16mmol/l ± 0.12 and 69±2.71μmol/l respectively. The mean systolic and diastolic blood pressures of the female patients were 158mmHg and 101mmHg, while those of the female controls were 101±2 and 62±9 respectively. The mean serum uric acid, fasting blood glucose, urea and creatinine of the female patients were 434umol/L, 5.3mmol/L 6.20mmol/L, and 88umol/L respectively while those for the female controls were 290±9μmol/l, 4.8±0.5mmol/l, 5.02±0.28 mmol/l, 62±0.36μmol/l respectively. Hyperuricaemia was observed in 59.3% of the male study patients and 62% of the female study patients. Serum uric acid correlated positively with both systolic blood pressure (r=0.192, p<0.001) and diastolic blood pressure (r=0.216; p<0.001). Hyperuricaemia is common among Nigerian patients with essential hypertension and there is an association between serum uric acid level and blood pressure. Further studies on the pathophysiologic significance of hyperuricaemia in these patients are recommended.
关于血清尿酸作为高血压和肾脏疾病独立危险因素的作用，目前仍存在争议。本研究测定了原发性高血压尼日利亚患者的血清尿酸水平，并评估了这些患者血清尿酸水平与血压之间的关联。这是一项对2004年1月至2008年12月期间在卡诺阿明努·卡诺教学医院高血压门诊就诊的351例原发性高血压患者进行的回顾性病例对照研究。对照组由100名明显健康的非高血压受试者组成。评估了包括血压测量、血清尿酸、尿素、肌酐、血脂谱和血糖在内的临床特征。男性患者的平均收缩压和舒张压分别为156mmHg和101mmHg，而男性对照组分别为120±6.0和80±5。男性研究患者的平均血清尿酸、空腹血糖、尿素和肌酐分别为483umol/L、5.7mmol/L、6.61mmol/L、93umol/l，而男性对照组分别为326±10μmol/l、5.0±0.5mmol/l、4.2±0.12mmol/l、5.16mmol/l±0.12和69±2.71μmol/l。女性患者的平均收缩压和舒张压分别为158mmHg和101mmHg，而女性对照组分别为101±2和62±9。女性患者的平均血清尿酸、空腹血糖、尿素和肌酐分别为434umol/L、5.3mmol/L、6.20mmol/L和88umol/L，而女性对照组分别为290±9μmol/l、4.8±0.5mmol/l、5.02±0.28mmol/l、62±0.36μmol/l。在59.3%的男性研究患者和62%的女性研究患者中观察到高尿酸血症。血清尿酸与收缩压（r=0.192，p<0.001）和舒张压（r=0.216；p<0.001）均呈正相关。高尿酸血症在尼日利亚原发性高血压患者中很常见，血清尿酸水平与血压之间存在关联。建议对这些患者高尿酸血症的病理生理意义进行进一步研究。
