Majethia Greesha N, Haq Wahajul, Balendiran Ganesaratnam K
Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA.
Results Chem. 2024 Jan;7. doi: 10.1016/j.rechem.2023.101282. Epub 2023 Dec 23.
Synthesis and characterization of drug metabolites has emerged as an important area of research in consideration to the significant contribution of studies on metabolites in drug research. The present work comprises synthesis of 2-(4-((4-chlorophenyl)(hydroxy)methyl) phenoxy)-2-methylpropanoic acid, a metabolite of anti-hyperlipidemic drug fenofibrate. The desired compound was prepared by two different synthetic routes. The ketone group of fenofibric acid was reduced using sodium borohydride in one route whereas the hydrolysis of isopropyl ester of the reduced fenofibrate was achieved by the mild alkaline hydrolysis in the other path. Both the ways of synthesis furnished the desired compound in excellent yield and purity. The new synthetic congener was characterized by spectroscopic methods.
考虑到代谢物研究在药物研究中的重大贡献，药物代谢物的合成与表征已成为一个重要的研究领域。目前的工作包括合成抗高血脂药物非诺贝特的一种代谢物2-(4-((4-氯苯基)(羟基)甲基)苯氧基)-2-甲基丙酸。通过两种不同的合成路线制备了所需化合物。在一条路线中，使用硼氢化钠还原非诺贝酸的酮基，而在另一条路线中，通过温和的碱性水解实现还原型非诺贝特异丙酯的水解。两种合成方法均以优异的产率和纯度得到了所需化合物。通过光谱方法对新的合成同系物进行了表征。
