OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.
Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Int J Mol Sci. 2023 Feb 19;24(4):4154. doi: 10.3390/ijms24044154.
Worldwide, prostate cancer (PC) is the second most frequent cancer among men and the fifth leading cause of death; moreover, standard treatments for PC have several issues, such as side effects and mechanisms of resistance. Thus, it is urgent to find drugs that can fill these gaps, and instead of developing new molecules requiring high financial and time investments, it would be useful to select non-cancer approved drugs that have mechanisms of action that could help in PC treatment, a process known as repurposing drugs. In this review article, drugs that have potential pharmacological efficacy are compiled to be repurposed for PC treatment. Thus, these drugs will be presented in the form of pharmacotherapeutic groups, such as antidyslipidemic drugs, antidiabetic drugs, antiparasitic drugs, antiarrhythmic drugs, anti-inflammatory drugs, antibacterial drugs, antiviral drugs, antidepressant drugs, antihypertensive drugs, antifungal drugs, immunosuppressant drugs, antipsychotic drugs, antiepileptic and anticonvulsant drugs, bisphosphonates and drugs for alcoholism, among others, and we will discuss their mechanisms of action in PC treatment.
在全球范围内，前列腺癌（PC）是男性中第二常见的癌症，也是第五大死亡原因；此外，PC 的标准治疗方法存在一些问题，如副作用和耐药机制。因此，迫切需要寻找能够填补这些空白的药物，而不是开发需要大量资金和时间投入的新分子，选择具有可能有助于 PC 治疗的作用机制的非癌症批准药物（即药物再利用）将是有用的。在这篇综述文章中，我们汇编了具有潜在药理功效的药物，以重新用于 PC 的治疗。因此，这些药物将以药物治疗组的形式呈现，如抗血脂药物、抗糖尿病药物、抗寄生虫药物、抗心律失常药物、抗炎药物、抗菌药物、抗病毒药物、抗抑郁药物、抗高血压药物、抗真菌药物、免疫抑制剂、抗精神病药物、抗癫痫和抗惊厥药物、双膦酸盐和酒精中毒药物等，我们将讨论它们在 PC 治疗中的作用机制。
