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The Impact of Cancer-Associated Fibroblasts on the Biology and Progression of Colorectal Carcinomas.癌症相关成纤维细胞对结直肠癌生物学和进展的影响。
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Phytomedicine. 2024 Apr;126:155462. doi: 10.1016/j.phymed.2024.155462. Epub 2024 Feb 16.
3
MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway.MDFI通过结合ITGB4/LAMB3激活AKT信号通路，促进结肠癌细胞的增殖及对化疗的耐受性。
Cancer Biol Ther. 2024 Dec 31;25(1):2314324. doi: 10.1080/15384047.2024.2314324. Epub 2024 Feb 20.
4
and antineoplastic activities of solamargine in colorectal cancer through the suppression of PI3K/AKT pathway.通过抑制 PI3K/AKT 通路，冬凌草甲素在结直肠癌中具有抗肿瘤活性。
Histol Histopathol. 2024 Oct;39(10):1317-1328. doi: 10.14670/HH-18-717. Epub 2024 Jan 31.
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Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways.橙皮素通过PI3K/AKT/FoxO3a和内质网应激-线粒体途径抑制膀胱癌细胞增殖并促进凋亡和细胞周期阻滞。
Curr Med Chem. 2024 Feb 13. doi: 10.2174/0109298673283888231217174702.
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SP1 Mediated PIK3CB Upregulation Promotes Gastric Carcinogenesis.SP1介导的PIK3CB上调促进胃癌发生。
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NDC1 promotes hepatocellular carcinoma tumorigenesis by targeting BCAP31 to activate PI3K/AKT signaling.NDC1 通过靶向 BCAP31 激活 PI3K/AKT 信号通路促进肝癌肿瘤发生。
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Villosol reverses 5-FU resistance in colorectal cancer by inhibiting the CDKN2A gene regulated TP53-PI3K/Akt signaling axis.维洛索尔通过抑制CDKN2A基因调控的TP53-PI3K/Akt信号轴来逆转结直肠癌中的5-氟尿嘧啶耐药性。
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Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer.磷脂酰肌醇-3-激酶信号通路在炎症相关癌症中的作用：rs10889677 变异和 buparlisib 在结肠炎相关癌症中的影响。
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肿瘤相关因子补体C1q/TNF相关蛋白6通过磷脂酰肌醇3激酶途径影响消化系统肿瘤的发生发展。

Tumor-related factor complement Clq/TNF-related protein 6 affects the development of digestive system tumors through the phosphatidylinositol 3-kinase pathway.

作者信息

Kong Mo-Wei, Li Xin-Rui, Gao Yu, Yang Ting-Fang

机构信息

Department of Cardiology, Guiqian International General Hospital, Guiyang 550018, Guizhou Province, China.

Department of Endocrinology, The Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China.

出版信息

World J Gastroenterol. 2024 Jul 14;30(26):3206-3209. doi: 10.3748/wjg.v30.i26.3206.

DOI:10.3748/wjg.v30.i26.3206
PMID:39086639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11287406/
Abstract

In this editorial, we review the work of Razali published in , with a particular focus on the effect of rs10889677 variation in the phosphatidylinositol 3-kinase (PI3K) pathway and buparlisib on colitis-associated cancer. The role of PI3K in promoting cancer progression has been widely recognized, as it is involved in regulating the survival, differentiation, and proliferation of cancer cells. The complement Clq/TNF-related protein 6 (CTRP6) is a newer tumor-associated factor. Recent studies have revealed the pro-tumor effect of CTRP6 in gastric cancer, hepatocellular carcinoma, colorectal cancer, and other gastrointestinal tumors through the PI3K pathway. This article attempts to reveal the mechanism through which the CTRP6 affects the development of digestive system tumors through the PI3K pathway by summarizing recent research.

摘要

在这篇社论中，我们回顾了拉扎利发表的研究工作，特别关注磷脂酰肌醇3激酶（PI3K）途径中的rs10889677变异以及布帕利昔对结肠炎相关癌症的影响。PI3K在促进癌症进展中的作用已得到广泛认可，因为它参与调节癌细胞的存活、分化和增殖。补体Clq/TNF相关蛋白6（CTRP6）是一种较新的肿瘤相关因子。最近的研究揭示了CTRP6通过PI3K途径在胃癌、肝细胞癌、结直肠癌和其他胃肠道肿瘤中的促肿瘤作用。本文试图通过总结近期研究来揭示CTRP6通过PI3K途径影响消化系统肿瘤发生发展的机制。