Al-Hashemi Ruaa W, Aldarraji Shumoos S, Abdalla Tasnim, Hasnah Sham, Abu-Dayeh Ala, Telfah Hussam Khalaf
Family Medicine, Primary Health Care Corporation, Doha, QAT.
Family Medicine Residency Program, Medical Education, Hamad Medical Corporation, Doha, QAT.
Cureus. 2024 Jun 30;16(6):e63542. doi: 10.7759/cureus.63542. eCollection 2024 Jun.
Rosai-Dorfman disease (RDD) is a rare disorder characterized by excessive growth of histiocytes. We present a case of a 14-year-old female with cutaneous RDD who had a subcutaneous lump on her left arm for three years. The lump became tender and progressively larger over the past year. She had no systemic symptoms, and her physical examination revealed a mobile, tender lump. Laboratory tests were normal. Surgical excision of the lump was performed, and histopathological examination confirmed RDD with the presence of epithelioid histiocytes with eosinophilic and clear cytoplasm, along with emperipolesis and positive staining for CD68, CD163, S100, and OCT2. The patient was referred for follow-up and required no further treatment. RDD can present with subcutaneous masses without systemic symptoms, and it is important to consider RDD in the differential diagnosis of such cases. Surgical excision is the main treatment, and long-term monitoring is necessary due to the potential for disease recurrence. Awareness of cutaneous RDD presentations is crucial for accurate diagnosis and management.
罗萨伊-多夫曼病（RDD）是一种罕见的疾病，其特征为组织细胞过度增生。我们报告一例14岁患有皮肤型RDD的女性病例，她左臂出现皮下肿块已有三年。在过去一年中，肿块变得触痛且逐渐增大。她没有全身症状，体格检查发现一个可活动、触痛的肿块。实验室检查正常。对肿块进行了手术切除，组织病理学检查确诊为RDD，可见上皮样组织细胞，其细胞质嗜酸性且透明，伴有血细胞吞噬现象，CD68、CD163、S100和OCT2染色呈阳性。该患者被转诊进行随访，无需进一步治疗。RDD可表现为无全身症状的皮下肿块，在对此类病例进行鉴别诊断时考虑RDD很重要。手术切除是主要治疗方法，由于疾病有复发的可能，长期监测是必要的。认识皮肤型RDD的表现对于准确诊断和管理至关重要。
