Chen Mingzhu, Hong Zhou, Shi Haicun, Wen Chunmei, Shen Yuan
Department of Neurology, Affiliated Hospital 6 of Nantong University, Yancheng, Jiangsu, China.
Department of Neurology, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
Front Neurol. 2024 Jul 17;15:1360222. doi: 10.3389/fneur.2024.1360222. eCollection 2024.
Stiff-person syndrome (SPS) is a rare neurological disorder characterized by chronic and progressive axial muscle rigidity and paroxysmal painful muscle spasms. The present case study described an SPS patient (increased anti-GAD65 antibody in serum and cerebrospinal fluid) with co-occurring Hashimoto's thyroiditis and decreased C3 complement levels. The clinical presentation, diagnostic approach, and treatment employed for this unique case were comprehensively described in detail. In this case, we comprehensively presented a case of SPS with co-occurring Hashimoto's thyroiditis and an associated decrease in serum C3 complement, as well as a discussion on the current data on this topic.
僵人综合征（SPS）是一种罕见的神经系统疾病，其特征为慢性进行性轴性肌肉僵硬和阵发性疼痛性肌肉痉挛。本病例研究描述了一名SPS患者（血清和脑脊液中抗GAD65抗体升高），同时患有桥本甲状腺炎且C3补体水平降低。详细全面地描述了针对这一特殊病例的临床表现、诊断方法及所采用的治疗。在此病例中，我们全面呈现了一例合并桥本甲状腺炎及血清C3补体降低的SPS病例，并对该主题的现有数据进行了讨论。
