Cheang Iokfai, Zhu Qingqing, Liao Shengen, Li Xinli
First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Front Mol Med. 2022 Jan 12;1:791931. doi: 10.3389/fmmed.2021.791931. eCollection 2021.
The relationship regarding non-coding genomes and cardiovascular disease (CVD) has been explored in the past decade. As one of the leading causes of death, there remains a lack of sensitive and specific genomic biomarkers in the diagnosis and prognosis of CVD. Piwi-interacting RNA (piRNA) is a group of small non-coding RNA (ncRNA) which associated with Piwi proteins. There is an emerging strong body of evidence in support of a role for ncRNAs, including piRNAs, in pathogenesis and prognosis of CVD. This article reviews the current evidence for piRNA-regulated mechanisms in CVD, which could lead to the development of new therapeutic strategies for prevention and treatment.
在过去十年中，人们对非编码基因组与心血管疾病（CVD）之间的关系进行了探索。作为主要死因之一，在CVD的诊断和预后方面，仍然缺乏敏感且特异的基因组生物标志物。Piwi相互作用RNA（piRNA）是一类与Piwi蛋白相关的小非编码RNA（ncRNA）。越来越多的有力证据支持包括piRNA在内的ncRNA在CVD发病机制和预后中发挥作用。本文综述了目前关于piRNA在CVD中调节机制的证据，这可能会促成预防和治疗CVD的新治疗策略的开发。
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