Zhang Tiantian, Han Yue, Wang Yongcheng, Wang Xiaoyu, Zhao Mingchen, Cheng Ziyang, Zhang Shiliang
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, China.
Department of Cardiovascular, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Eur J Med Res. 2025 Jul 21;30(1):643. doi: 10.1186/s40001-025-02851-6.
Myocardial ischemia-reperfusion injury (MIRI) is a common fatal event in cardiovascular diseases. Oxidative stress, energy metabolism disorders, and inflammatory responses that occur during this process cause severe damage to myocardial cells. Ferroptosis is a novel form of cell death closely related to cellular damage in MIRI. Numerous studies have demonstrated that specific active ingredients can regulate iron homeostasis and inhibit ferroptosis, thereby protecting myocardial function and enhancing the prognosis of patients. At the same time, traditional Chinese medicine monomers also provide a new perspective for the treatment of MIRI. This review summarizes the recent advances in understanding the mechanisms underlying ferroptosis, with the aim of providing potential novel therapeutic strategies for the clinical management of MIRI.
心肌缺血再灌注损伤（MIRI）是心血管疾病中常见的致命事件。在此过程中发生的氧化应激、能量代谢紊乱和炎症反应会对心肌细胞造成严重损伤。铁死亡是一种与MIRI中的细胞损伤密切相关的新型细胞死亡形式。大量研究表明，特定的活性成分可以调节铁稳态并抑制铁死亡，从而保护心肌功能并改善患者的预后。同时，中药单体也为MIRI的治疗提供了新的视角。本综述总结了近年来在理解铁死亡潜在机制方面的进展，旨在为MIRI的临床管理提供潜在的新型治疗策略。
