Gong Ling-Zhen, Wang Qian-Wen, Zhu Jie-Wen
Department of Clinical Laboratory, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, Huangshi 435000, Hubei Province, China.
World J Gastrointest Surg. 2024 Jul 27;16(7):2073-2079. doi: 10.4240/wjgs.v16.i7.2073.
Hepatic metastases are common and difficult to treat after colorectal cancer (CRC) surgery. The predictive value of carcinoembryonic antigen (CEA), cancer antigen (CA) 125 and CA19-9 combined tests for liver metastasis is unclear.
To evaluate predictive value of combined tests for CEA, CA125, and CA19-9 levels in patients with liver metastases of CRC.
The retrospective study included patients with CRC alone (50 cases) and patients with CRC combined with liver metastases (50 cases) who were hospitalized between January 2021 and January 2023. Serum CEA, CA125 and CA19-9 levels were compared between the two groups, and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver metastasis. In addition, we performed receiver operating characteristic (ROC) curve analysis to assess its diagnostic accuracy.
The results showed that the serum CEA, CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone group. Specifically, the average serum CEA level in the CRC with liver metastasis group was 162.03 ± 810.01 ng/mL, while that in the CRC alone group was 5.71 ± 9.76 ng/mL; the average serum CA125 levels were 43.47 ± 83.52 U/mL respectively. and 13.5 ± 19.68 U/mL; the average serum CA19-9 levels were 184.46 ± 473.13 U/mL and 26.55 ± 43.96 U/mL respectively. In addition, binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis ( < 0.05). ROC curve analysis results showed that the areas under the ROC curves of CEA, CA125 and CA19-9 were 0.607, 0.692 and 0.586.
These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis, thereby improving patient prognosis.
肝转移在结直肠癌（CRC）手术后很常见且难以治疗。癌胚抗原（CEA）、癌抗原（CA）125和CA19 - 9联合检测对肝转移的预测价值尚不清楚。
评估CEA、CA125和CA19 - 9联合检测对CRC肝转移患者的预测价值。
这项回顾性研究纳入了2021年1月至2023年1月期间住院的单纯CRC患者（50例）和CRC合并肝转移患者（50例）。比较两组患者的血清CEA、CA125和CA19 - 9水平，并采用二元逻辑回归分析这些肿瘤标志物联合检测在肝转移中的预测价值。此外，我们进行了受试者工作特征（ROC）曲线分析以评估其诊断准确性。
结果显示，CRC合并肝转移组的血清CEA、CA125和CA19 - 9水平显著高于单纯CRC组。具体而言，CRC合并肝转移组的血清CEA平均水平为162.03±810.01 ng/mL，而单纯CRC组为5.71±9.76 ng/mL；血清CA125平均水平分别为43.47±83.52 U/mL和13.5±19.68 U/mL；血清CA19 - 9平均水平分别为184.46±473.13 U/mL和26.55±43.96 U/mL。此外，二元逻辑回归分析显示CA125在预测CRC肝转移方面具有显著性（<0.05）。ROC曲线分析结果显示，CEA、CA125和CA19 - 9的ROC曲线下面积分别为0.607、0.692和0.586。
这些结果表明，联合检测这些肿瘤标志物可能有助于CRC肝转移的早期检测和干预，从而改善患者预后。
