Li Ru-Jia, Yang Ting, Zeng Yu-Hao, Natsuyama Yutaro, Ren Ke, Li Jun, Nagakawa Yuichi, Yi Shuang-Qin
Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan.
Faculty of Physical Education, Qujing Normal University, Qujing 655000, Yunnan Province, China.
World J Gastrointest Surg. 2024 Jul 27;16(7):2308-2318. doi: 10.4240/wjgs.v16.i7.2308.
Surgical intervention involving the pancreas can lead to impaired glucose tolerance and other types of endocrine dysfunction. The scope of pancreatectomy and whether it includes the ventral pancreas are the key factors in the development of postoperative diabetes. The ventral and dorsal pancreases are almost separated in ().
To investigate the effects of different extents of pancreatic resection on endocrine function in .
Eight-week-old male shrews were randomly divided into three experimental groups according to different pancreatic resection ranges as follows: ventral pancreatectomy (VPx) group; partial pancreatectomy (PPx) group; subtotal pancreatectomy (SPx) group; and a sham-operated group. Postprandial serum insulin, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and somatostatin (SST) levels, as well as food intake, weight, blood glucose, and glucose tolerance were regularly measured for each animal.
treated with PPx and SPx suffered from varying degrees of impaired glucose tolerance, but only a small proportion of the SPx group developed diabetes. Only in the SPx group showed a significant decrease in food intake accompanied by severe weight loss, as well as a significant increase in postprandial serum GLP-1 levels. Postprandial serum PP levels decreased in both the VPx and PPx groups, but not in the SPx group. Postprandial serum SST levels decreased in both VPx and PPx groups, but the decrease was marginal.
Severe weight loss after pancreatectomy may be related to loss of appetite caused by compensatory elevation of GLP-1. PP and GLP-1 may play a role in resisting blood glucose imbalance.
涉及胰腺的外科手术干预可导致糖耐量受损和其他类型的内分泌功能障碍。胰腺切除术的范围以及是否包括腹侧胰腺是术后糖尿病发生的关键因素。腹侧和背侧胰腺在（）中几乎分离。
研究不同程度胰腺切除对（）内分泌功能的影响。
将8周龄雄性（）鼩鼱根据不同的胰腺切除范围随机分为三个实验组，如下：腹侧胰腺切除术（VPx）组；部分胰腺切除术（PPx）组；次全胰腺切除术（SPx）组；以及假手术组。定期测量每只动物的餐后血清胰岛素、胰高血糖素样肽-1（GLP-1）、胰多肽（PP）和生长抑素（SST）水平，以及食物摄入量、体重、血糖和糖耐量。
接受PPx和SPx治疗的动物出现不同程度的糖耐量受损，但只有一小部分SPx组动物发生糖尿病。只有SPx组的（）出现食物摄入量显著减少并伴有严重体重减轻，以及餐后血清GLP-1水平显著升高。VPx组和PPx组的餐后血清PP水平均下降，但SPx组未下降。VPx组和PPx组的餐后血清SST水平均下降，但下降幅度较小。
胰腺切除术后的严重体重减轻可能与GLP-1代偿性升高引起的食欲丧失有关。PP和GLP-1可能在抵抗血糖失衡中起作用。
