Zhao Yongjian, Tan Mingyue, Yin Yunfei, Zhang Jun, Song Yiyi, Li Hang, Yan Lin, Jin Yifeng, Wu Ziyue, Yang Tianke, Jiang Tingbo, Li Hongxia
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Geriatrics, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.
Cell Prolif. 2024 Dec;57(12):e13725. doi: 10.1111/cpr.13725. Epub 2024 Aug 1.
Ischemic heart disease (IHD) is a prevalent cardiovascular condition that remains the primary cause of death due to its adverse ventricular remodelling and pathological changes in end-stage heart failure. As a complex pathologic condition, it involves intricate regulatory processes at the cellular and molecular levels. The immune system and cardiovascular system are closely interconnected, with immune cells playing a crucial role in maintaining cardiac health and influencing disease progression. Consequently, alterations in the cardiac microenvironment are influenced and controlled by various immune cells, such as macrophages, neutrophils, dendritic cells, eosinophils, and T-lymphocytes, along with the cytokines they produce. Furthermore, studies have revealed that Gata6 pericardial cavity macrophages play a key role in regulating immune cell migration and subsequent myocardial tissue repair post IHD onset. This review outlines the role of immune cells in orchestrating inflammatory responses and facilitating myocardial repair following IHD, considering both macro and micro views. It also discusses innovative immune cell-based therapeutic strategies, offering new insights for further research on the pathophysiology of ischemic heart disease and immune cell-targeted therapy for IHD.
缺血性心脏病（IHD）是一种常见的心血管疾病，由于其不良的心室重构和终末期心力衰竭的病理变化，仍然是主要的死亡原因。作为一种复杂的病理状况，它涉及细胞和分子水平上错综复杂的调节过程。免疫系统和心血管系统紧密相连，免疫细胞在维持心脏健康和影响疾病进展方面发挥着关键作用。因此，心脏微环境的改变受到各种免疫细胞的影响和控制，如巨噬细胞、中性粒细胞、树突状细胞、嗜酸性粒细胞和T淋巴细胞，以及它们产生的细胞因子。此外，研究表明，Gata6心包腔巨噬细胞在调节免疫细胞迁移以及IHD发作后随后的心肌组织修复中起关键作用。本综述从宏观和微观角度概述了免疫细胞在协调IHD后的炎症反应和促进心肌修复中的作用。它还讨论了基于免疫细胞的创新治疗策略，为缺血性心脏病病理生理学的进一步研究和IHD的免疫细胞靶向治疗提供了新的见解。
