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Cardioprotective effects of ghrelin and Wharton's jelly-derived mesenchymal stem cells, alone and in combination, in doxorubicin-induced myocardial injury in rats.

作者信息

Boushra Amy F, Yacoub Christina Sabry, Osman Hamed Mohamed, Ali Amani M El Amin, Elamir Azza Mohamed, Elsayed Asmaa Mohamed, Gamal Sarah Mahmoud

机构信息

Department of Medical Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

出版信息

J Mol Histol. 2025 Aug 29;56(5):285. doi: 10.1007/s10735-025-10567-4.

DOI:10.1007/s10735-025-10567-4
PMID:40879836
Abstract
摘要

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1
Cardioprotective effects of ghrelin and Wharton's jelly-derived mesenchymal stem cells, alone and in combination, in doxorubicin-induced myocardial injury in rats.胃饥饿素与沃顿胶源性间充质干细胞单独及联合应用对阿霉素诱导的大鼠心肌损伤的心脏保护作用
J Mol Histol. 2025 Aug 29;56(5):285. doi: 10.1007/s10735-025-10567-4.
2
Synergistic effect of Wharton's jelly-derived mesenchymal stem cells and insulin on Schwann cell proliferation in Charcot-Marie-Tooth disease type 1A treatment.华通氏胶源性间充质干细胞与胰岛素对1A型遗传性运动感觉神经病治疗中施万细胞增殖的协同作用。
Neurobiol Dis. 2024 Dec;203:106725. doi: 10.1016/j.nbd.2024.106725. Epub 2024 Nov 12.
3
Therapeutic Effect of Wharton's Jelly-Derived Mesenchymal Stem Cells and Conditioned Medium in a Carbon Dioxide Laser Burn Model: An Experimental Study.脐带华通氏胶间充质干细胞及其条件培养基在二氧化碳激光烧伤模型中的治疗作用：一项实验研究
Ann Plast Surg. 2025 Apr 4. doi: 10.1097/SAP.0000000000004343.
4
Treatment With Human Wharton's Jelly-Derived Mesenchymal Stem Cells Attenuates Sepsis-Induced Kidney Injury, Liver Injury, and Endothelial Dysfunction.用人脐带华通氏胶间充质干细胞治疗可减轻脓毒症诱导的肾损伤、肝损伤和内皮功能障碍。
Stem Cells Transl Med. 2016 Aug;5(8):1048-57. doi: 10.5966/sctm.2015-0138. Epub 2016 Jun 8.
5
Single high-dose intravenous injection of Wharton's jelly-derived mesenchymal stem cell exerts protective effects in a rat model of metabolic syndrome.单次大剂量静脉注射牙髓间充质干细胞在代谢综合征大鼠模型中发挥保护作用。
Stem Cell Res Ther. 2024 Jun 5;15(1):160. doi: 10.1186/s13287-024-03769-2.
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A GMP-compliant manufacturing method for Wharton's jelly-derived mesenchymal stromal cells.符合 GMP 标准的人脐带华通氏胶源间充质基质细胞制造方法。
Stem Cell Res Ther. 2024 May 3;15(1):131. doi: 10.1186/s13287-024-03725-0.
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Enhancing adipogenesis in Wharton's jelly multipotent mesenchymal stromal cells through lipidomic insights and fatty acid supplementation.通过脂质组学见解和脂肪酸补充增强脐带来源的多能间充质基质细胞的脂肪生成
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J Endovasc Ther. 2025 Aug 23:15266028251361770. doi: 10.1177/15266028251361770.
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Wharton's jelly-derived mesenchymal stem cells attenuate sepsis-induced organ injury partially via cholinergic anti-inflammatory pathway activation.华通氏胶源间充质干细胞通过胆碱能抗炎途径的激活部分减轻脓毒症诱导的器官损伤。
Am J Physiol Regul Integr Comp Physiol. 2020 Jan 1;318(1):R135-R147. doi: 10.1152/ajpregu.00098.2018. Epub 2019 Oct 9.
10
Intranasal Wharton's Jelly-Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic-Ischemic Brain Injury in Mice.经鼻给予源自沃顿胶的间充质干细胞疗法，单独使用或与治疗性低温联合使用，可减轻小鼠新生儿缺氧缺血性脑损伤。
Ann Neurol. 2025 Aug 26. doi: 10.1002/ana.78000.

本文引用的文献

1
Mesenchymal stem cells as future treatment for cardiovascular regeneration and its challenges.间充质干细胞作为心血管再生的未来治疗方法及其面临的挑战。
Ann Transl Med. 2024 Aug 1;12(4):73. doi: 10.21037/atm-23-1936. Epub 2023 Dec 29.
2
Comprehensive macro and micro views on immune cells in ischemic heart disease.关于缺血性心脏病中免疫细胞的全面宏观和微观观点。
Cell Prolif. 2024 Dec;57(12):e13725. doi: 10.1111/cpr.13725. Epub 2024 Aug 1.
3
The significance of the apelinergic system in doxorubicin-induced cardiotoxicity.阿片肽能系统在阿霉素诱导的心脏毒性中的意义。
Heart Fail Rev. 2024 Sep;29(5):969-988. doi: 10.1007/s10741-024-10414-w. Epub 2024 Jul 11.
4
Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.胃饥饿素通过 DDX17 介导的 SFRP4/Wnt/β-连环蛋白轴调节促进脂肪组织来源的间充质干细胞向心肌细胞分化。
Mol Med Rep. 2023 Sep;28(3). doi: 10.3892/mmr.2023.13050. Epub 2023 Jul 14.
5
Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation.胸腺醌通过减轻氧化应激和炎症对β受体刺激的心肌梗死大鼠产生心脏保护作用。
Nutrients. 2022 Jun 30;14(13):2742. doi: 10.3390/nu14132742.
6
Ghrelin ameliorates transformation of hepatic ischemia-reperfusion injury to liver fibrosis by blocking Smad and ERK signalling pathways, and promoting anti-inflammation and anti-oxidation effects.Ghrelin 通过阻断 Smad 和 ERK 信号通路，促进抗炎和抗氧化作用，改善肝缺血再灌注损伤向肝纤维化的转化。
Transpl Immunol. 2022 Aug;73:101597. doi: 10.1016/j.trim.2022.101597. Epub 2022 Apr 3.
7
Therapeutic Targets for DOX-Induced Cardiomyopathy: Role of Apoptosis vs. Ferroptosis.多柔比星诱导性心肌病的治疗靶点：细胞凋亡与铁死亡的作用。
Int J Mol Sci. 2022 Jan 26;23(3):1414. doi: 10.3390/ijms23031414.
8
Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury.Nrf2 对心脏损伤中氧化剂生成和线粒体损伤的保护作用。
Free Radic Biol Med. 2022 Feb 1;179:133-143. doi: 10.1016/j.freeradbiomed.2021.12.001. Epub 2021 Dec 16.
9
Ghrelin ameliorated inflammation and oxidative stress in isoproterenol induced myocardial infarction through the endothelial nitric oxide synthase (eNOS)/nuclear factor erythroid 2-related factor-2 (NRF2)/heme oxygenase-1 (HO-1) signaling pathway.胃饥饿素通过内皮型一氧化氮合酶（eNOS）/核因子红细胞2相关因子2（NRF2）/血红素加氧酶1（HO-1）信号通路改善异丙肾上腺素诱导的心肌梗死中的炎症和氧化应激。
J Physiol Pharmacol. 2021 Apr;72(2). doi: 10.26402/jpp.2021.2.12. Epub 2021 Jul 10.
10
Dose-Dependent Cardioprotective Effect of Hemin in Doxorubicin-Induced Cardiotoxicity Via Nrf-2/HO-1 and TLR-5/NF-κB/TNF-α Signaling Pathways.血红素通过 Nrf-2/HO-1 和 TLR-5/NF-κB/TNF-α 信号通路对阿霉素诱导的心脏毒性的剂量依赖性保护作用。
Cardiovasc Toxicol. 2021 Dec;21(12):1033-1044. doi: 10.1007/s12012-021-09694-7. Epub 2021 Sep 11.