Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pediatr Allergy Immunol. 2024 Aug;35(8):e14208. doi: 10.1111/pai.14208.
We investigated the individual and interaction effects of maternal plasma 𝛂- and ϒ-tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8-9.
Mother-child dyads were enrolled between 2006 and 2011 into the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) prenatal cohort. Maternal second-trimester samples were analyzed for tocopherol and lipid concentrations. We assessed child asthma/wheeze using the International Study of Asthma and Allergies in Childhood (ISAAC) and other self-reported Ent wheeze. In multivariable logistic regression analyses, we assessed associations between vitamin E isomers and child asthma/wheeze outcomes (n = 847 mother-child dyads) and tested for prespecified interaction terms.
Median cholesterol-corrected tocopherol levels (interquartile range (IQR)) were 5.0 (4.3-5.7) and 0.8 (0.7-0.9) (umol/mmol) for 𝛂- and ϒ-tocopherol, respectively. Associations between 𝛂-tocopherol and asthma outcome variables were inverse but not statistically significant. In contrast, for ϒ-tocopherol, associations were in the positive direction, but also nonsignificant. Interactions analysis between tocopherols did not reach statistical significance for any outcome. Among children of women with a history of asthma, the likelihood of ever asthma in the child appears to be decreasing with increasing maternal 𝛂-tocopherol levels, whereas this trend was not observed among those without a history of asthma (p-interaction = .05).
We observed no associations for prenatal 𝛂- or ϒ-tocopherol concentrations with child asthma/wheeze. We detected some evidence of effect modification by maternal asthma history in associations between 𝛂-tocopherol and child asthma.
我们研究了母体血浆 α-和 γ-生育酚水平（维生素 E 异构体）对 8-9 岁儿童哮喘和喘息的个体和交互作用。
在 2006 年至 2011 年期间，母婴对子被纳入条件影响神经认知发育和儿童期学习（CANDLE）产前队列。分析母体中期样本中的生育酚和脂质浓度。我们使用国际儿童哮喘和过敏研究（ISAAC）和其他自我报告的 Ent 喘息评估儿童哮喘/喘息。在多变量逻辑回归分析中，我们评估了维生素 E 异构体与儿童哮喘/喘息结局之间的关联（n=847 对母婴对子），并测试了预设的交互项。
中位数胆固醇校正生育酚水平（四分位距（IQR））分别为 5.0（4.3-5.7）和 0.8（0.7-0.9）（umol/mmol），用于 α-和 γ-生育酚。α-生育酚与哮喘结局变量之间的关联呈负相关，但无统计学意义。相比之下，对于 γ-生育酚，关联呈正方向，但也无统计学意义。生育酚之间的交互分析对于任何结局都没有达到统计学意义。在有哮喘病史的女性的孩子中，孩子曾经患哮喘的可能性似乎随着母体 α-生育酚水平的增加而降低，而在没有哮喘病史的女性中则没有观察到这种趋势（p 交互=0.05）。
我们没有观察到产前 α-或 γ-生育酚浓度与儿童哮喘/喘息之间存在关联。我们检测到母体哮喘史与 α-生育酚和儿童哮喘之间关联的一些效应修饰证据。
