Zilinskas Kasparas, Mittal Rohit, Hollowed Kathleen, Kahn Steven A
Department of Burn Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
J Burn Care Res. 2025 Jan 24;46(1):178-182. doi: 10.1093/jbcr/irae146.
CO2 ablative fractional laser (CO2 AFL) therapy is a safe and effective procedure when used in the treatment of hypertrophic scars for burn patients. It has a high patient satisfaction rate and a minimal side effect profile, typically consisting of postoperative pain, irritation, surgical site inflammation, and, in rare cases, infection. Although prophylactic antibiotics have historically been recommended, there is a paucity of literature on the topic and recent studies indicate that they may be unnecessary in routine cases. In this retrospective, single-center descriptive study, 230 cases in patients with hypertrophic burn scars treated with CO2 AFL therapy were compared. 28 cases were with the use of prophylactic antibiotics and 201 cases were without the use of prophylactic antibiotics. We found that there was no significant association between the use of antibiotics and the prevention of topical skin infection in cases treated with CO2 AFL therapy (P = 1). Therefore, we conclude that the omission of prophylactic antibiotics is not associated with an increased risk of infection and recommend that prophylactic antibiotics should not be indicated in the setting of routine CO2 AFL therapy for patients with hypertrophic burn scars.
二氧化碳剥脱性分次激光（CO2 AFL）疗法用于治疗烧伤患者的增生性瘢痕时是一种安全有效的方法。它具有较高的患者满意率，且副作用极小，通常包括术后疼痛、刺激、手术部位炎症，以及罕见的感染。尽管以往一直推荐使用预防性抗生素，但关于这一主题的文献较少，且近期研究表明，在常规病例中可能无需使用。在这项回顾性单中心描述性研究中，对230例接受CO2 AFL疗法治疗的烧伤增生性瘢痕患者进行了比较。28例使用了预防性抗生素，201例未使用预防性抗生素。我们发现，在接受CO2 AFL疗法治疗的病例中，使用抗生素与预防局部皮肤感染之间无显著关联（P = 1）。因此，我们得出结论，不使用预防性抗生素与感染风险增加无关，并建议在对烧伤增生性瘢痕患者进行常规CO2 AFL治疗时不使用预防性抗生素。
