School of Optometry, The Hong Kong Polytechnic University.
Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong.
J Glaucoma. 2024 Nov 1;33(11):874-879. doi: 10.1097/IJG.0000000000002478. Epub 2024 Aug 2.
High perceived stress from academic pressure is associated with intraocular pressure (IOP) elevation and reduced fluctuation in juvenile-onset open angle glaucoma patients. Personalized stress assessment and relief strategies may serve as an adjunct therapy in glaucoma.
To evaluate the effect of higher perceived stress, resulting from academic pressure, on IOP in juvenile-onset open angle glaucoma (JOAG) patients compared with healthy individuals.
The study included 48 university students aged 18-27 years, comprising 24 JOAG patients on antiglaucoma eyedrops and 24 healthy controls. In an examiner-blind pretest-posttest design, participants' IOP was measured weekly using Goldmann tonometry during three follow-up visits at the beginning and end of the academic semester. Perceived Stress Scale (PSS) scores were also evaluated at these 2-time points to capture the contrast in perceived stress between periods of low and high academic pressure.
The baseline PSS score at the semester's start was lower in both groups (14.1±1.9 in glaucoma vs. 13.5±2.4 in control) and significantly increased by the end of the semester (29.2±2.1 vs. 28.5±1.3; P <0.001), indicating increased perceived stress. Concurrently, IOP rose from 22.01±5.87 to 25.08±5.84 mm Hg in the glaucoma group and from 11.36±2.03 to 13.65±2.11 mm Hg in the control group. Factorial analysis revealed a significant interaction between stress and JOAG ( F(1,94) =15.94, P =0.001), partial η 2 =0.08, with stress having a greater increase on IOP in the glaucoma group (+3.10 mm Hg) compared with the control group (+2.23 mm Hg) ( t(94) =4.457, P <0.001).
Higher perceived stress significantly increases IOP, especially in JOAG patients, suggesting personalized stress management as a potential adjunct therapy for patients.
高感知压力与青少年开角型青光眼患者的眼压升高和波动减少有关。个性化的压力评估和缓解策略可能作为青光眼的辅助治疗。
评估与健康个体相比，源于学业压力的高感知压力对青少年开角型青光眼（JOAG）患者眼压的影响。
本研究纳入了 48 名年龄在 18-27 岁之间的大学生，包括 24 名接受抗青光眼滴眼液治疗的 JOAG 患者和 24 名健康对照者。采用盲法、前后测设计，在学期开始和结束时进行 3 次随访，每周使用 Goldmann 眼压计测量参与者的眼压。在这 2 个时间点还评估了感知压力量表（PSS）评分，以捕捉学业压力高低期间感知压力的差异。
学期开始时，两组的基线 PSS 评分均较低（青光眼组为 14.1±1.9，对照组为 13.5±2.4），且在学期末显著升高（青光眼组为 29.2±2.1，对照组为 28.5±1.3；P<0.001），表明感知压力增加。同时，青光眼组的眼压从 22.01±5.87 升高至 25.08±5.84mmHg，对照组从 11.36±2.03 升高至 13.65±2.11mmHg。方差分析显示，压力与 JOAG 之间存在显著交互作用（F(1,94)=15.94，P=0.001），部分η 2=0.08，青光眼组的眼压升高幅度（3.10mmHg）明显大于对照组（2.23mmHg）（t(94)=4.457，P<0.001）。
高感知压力显著增加眼压，尤其是在 JOAG 患者中，提示个性化压力管理可能是患者的一种潜在辅助治疗方法。
