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树突状细胞的可塑性、辐射和牛顿第三定律。

Dendritic Cell Plasticity, Radiation, and Newton's Third Law.

机构信息

Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

出版信息

Clin Cancer Res. 2024 Oct 1;30(19):4260-4262. doi: 10.1158/1078-0432.CCR-24-1506.

DOI:10.1158/1078-0432.CCR-24-1506
PMID:39087954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446472/
Abstract

Regulatory T cells protect damaged tissues but can undermine the effects of cancer treatments, including radiotherapy (RTx). Intratumoral immunostimulatory dendritic cells (type 1 conventional dendritic cells) respond to RTx with the production of regulatory T cell-attracting MDC/CCL22, undermining RTx effects. That effect can be reversed by EGFR-targeted IFNα, highlighting cDC1 plasticity and relevance as therapeutic targets. See related article by Bugno et al., p. 4450.

摘要

调节性 T 细胞可保护受损组织，但也会削弱癌症治疗的效果，包括放疗（RTx）。肿瘤内免疫刺激树突状细胞（1 型传统树突状细胞）对 RTx 的反应是产生吸引调节性 T 细胞的 MDC/CCL22，从而削弱 RTx 的效果。这种效应可以被 EGFR 靶向 IFNα逆转，突出了 cDC1 的可塑性和作为治疗靶点的相关性。见 Bugno 等人的相关文章，第 4450 页。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/902e/11446472/8a14c198539b/nihms-2008489-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/902e/11446472/8a14c198539b/nihms-2008489-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/902e/11446472/8a14c198539b/nihms-2008489-f0001.jpg

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本文引用的文献

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Clin Cancer Res. 2024 Oct 1;30(19):4450-4463. doi: 10.1158/1078-0432.CCR-23-3616.
2
Systemic infusion of TLR3-ligand and IFN-α in patients with breast cancer reprograms local tumor microenvironments for selective CTL influx.系统性输注 TLR3 配体和 IFN-α 可重塑乳腺癌患者局部肿瘤微环境以选择性募集 CTL。
J Immunother Cancer. 2023 Nov;11(11). doi: 10.1136/jitc-2023-007381.
3
Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities.
肿瘤部位的适应性免疫抵抗：机制与治疗机会。
Nat Rev Drug Discov. 2022 Jul;21(7):529-540. doi: 10.1038/s41573-022-00493-5. Epub 2022 Jun 14.
4
Radiation therapy-induced remodeling of the tumor immune microenvironment.放疗诱导的肿瘤免疫微环境重塑。
Semin Cancer Biol. 2022 Nov;86(Pt 2):737-747. doi: 10.1016/j.semcancer.2022.04.003. Epub 2022 Apr 9.
5
Radiotherapy and immunotherapy: open questions and future strategies.放疗与免疫治疗：悬而未决的问题与未来策略
Trends Cancer. 2022 Jan;8(1):9-20. doi: 10.1016/j.trecan.2021.10.003. Epub 2021 Nov 2.
6
cDC1 dysregulation in cancer: An opportunity for intervention.癌症中 cDC1 失调：干预的机会。
J Exp Med. 2020 Aug 3;217(8). doi: 10.1084/jem.20200816.
7
Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment.解旋酶驱动的 NFκB-COX2 通路激活介导了人肿瘤微环境中双链 RNA 驱动炎症的免疫抑制成分。
Cancer Res. 2018 Aug 1;78(15):4292-4302. doi: 10.1158/0008-5472.CAN-17-3985. Epub 2018 May 31.
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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.DNA 外切酶 Trex1 调控放疗诱导的肿瘤免疫原性。
Nat Commun. 2017 Jun 9;8:15618. doi: 10.1038/ncomms15618.
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Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment.IFNγ 和 TNFα 协同诱导 COX2 自我限制人类肿瘤微环境中的 1 型免疫。
Cancer Immunol Res. 2016 Apr;4(4):303-11. doi: 10.1158/2326-6066.CIR-15-0157. Epub 2016 Jan 27.
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TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.转化生长因子β是放射治疗诱导的抗肿瘤免疫的主要调节因子。
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