树突状细胞的可塑性、辐射和牛顿第三定律。
Dendritic Cell Plasticity, Radiation, and Newton's Third Law.
机构信息
Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
出版信息
Clin Cancer Res. 2024 Oct 1;30(19):4260-4262. doi: 10.1158/1078-0432.CCR-24-1506.
Abstract
Regulatory T cells protect damaged tissues but can undermine the effects of cancer treatments, including radiotherapy (RTx). Intratumoral immunostimulatory dendritic cells (type 1 conventional dendritic cells) respond to RTx with the production of regulatory T cell-attracting MDC/CCL22, undermining RTx effects. That effect can be reversed by EGFR-targeted IFNα, highlighting cDC1 plasticity and relevance as therapeutic targets. See related article by Bugno et al., p. 4450.
摘要
调节性 T 细胞可保护受损组织，但也会削弱癌症治疗的效果，包括放疗（RTx）。肿瘤内免疫刺激树突状细胞（1 型传统树突状细胞）对 RTx 的反应是产生吸引调节性 T 细胞的 MDC/CCL22，从而削弱 RTx 的效果。这种效应可以被 EGFR 靶向 IFNα逆转，突出了 cDC1 的可塑性和作为治疗靶点的相关性。见 Bugno 等人的相关文章，第 4450 页。
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本文引用的文献
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Systemic infusion of TLR3-ligand and IFN-α in patients with breast cancer reprograms local tumor microenvironments for selective CTL influx.系统性输注 TLR3 配体和 IFN-α 可重塑乳腺癌患者局部肿瘤微环境以选择性募集 CTL。
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