Department of Pathology, University of Chicago, Chicago, IL.
Department of Medicine, University of Chicago, Chicago, IL.
J Exp Med. 2020 Aug 3;217(8). doi: 10.1084/jem.20200816.
Conventional dendritic cells driven by the transcription factor Batf3 (cDC1 cells) are critical for the activation and maintenance of tumor-specific CD8+ T cells. In this issue of JEM, Lin et al. (https://doi.org/10.1084/jem.20190673) demonstrate systemic dysfunction of cDC1 cells in pancreatic cancer, which offers potential treatment strategies to expand the benefit of checkpoint blockade immunotherapy.
转录因子 Batf3 驱动的传统树突状细胞（cDC1 细胞）对于肿瘤特异性 CD8+ T 细胞的激活和维持至关重要。在本期《JEM》中，Lin 等人（https://doi.org/10.1084/jem.20190673）证明了胰腺癌细胞中 cDC1 细胞的全身功能障碍，这为扩大检查点阻断免疫疗法的获益提供了潜在的治疗策略。
