Université de Reims Champagne-Ardenne, CNRS, ICMR, 51687, Reims Cedex 2, France.
Université de Reims Champagne-Ardenne, BIOS, Reims, France, 51100.
ChemMedChem. 2024 Nov 18;19(22):e202400245. doi: 10.1002/cmdc.202400245. Epub 2024 Sep 24.
A series of Au(I) complexes containing unsymmetrical N-heterocyclic carbene (imidazolylidene and benzimidazolylidene) functionalized with a xyloside group and an alkyl moiety (methyl and mesityl) was prepared using efficient procedures from D-xylose. Their characterization was carried out in solution by multinuclear NMR, HR-MS spectrometry and cyclic voltammetry, as well as in the solid state by means of single crystal X-ray diffraction analysis for two of them. Evaluation of their ability to inhibit bacterial growth showed a preference for a Gram-positive strain, Staphylococcus aureus, over a Gram-negative strain, Pseudomonas aeruginosa.
一系列含有不对称 N-杂环卡宾（咪唑基和苯并咪唑基）的金（I）配合物，用木糖衍生的糖基（甲氧基和均三甲氧基）和烷基部分（甲基和均三甲基）进行功能化，通过高效的方法从 D-木糖中制备。通过多核 NMR、高分辨率质谱、循环伏安法在溶液中，以及通过单晶 X 射线衍射分析对其中两种配合物在固态下对其进行了表征。评估它们抑制细菌生长的能力表明，它们更倾向于抑制革兰氏阳性菌金黄色葡萄球菌，而不是革兰氏阴性菌铜绿假单胞菌。
