Fernández Gabriela A, Vela Gurovic María S, Olivera Nelda L, Chopa Alicia B, Silbestri Gustavo F
INQUISUR, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, B8000CPB Bahía Blanca, Argentina.
INQUISUR, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, B8000CPB Bahía Blanca, Argentina.
J Inorg Biochem. 2014 Jun;135:54-7. doi: 10.1016/j.jinorgbio.2014.03.001. Epub 2014 Mar 11.
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.
通过琼脂扩散法和肉汤宏观稀释法，针对革兰氏阳性菌金黄色葡萄球菌、粪肠球菌和藤黄微球菌以及革兰氏阴性菌鲁氏耶尔森菌、铜绿假单胞菌和大肠杆菌，评估了水溶性金（I）配合物[1-甲基-3-（3-磺丙基）咪唑-2-亚基]氯化金（I）（C1）、[1-均三甲苯基-3-（3-磺丙基）咪唑-2-亚基]氯化金（I）（C2）、[1-（2,6-二异丙基苯基）-3-（3-磺丙基）咪唑-2-亚基]氯化金（I）（C3）和[1,3-双（2,6-二异丙基-4-磺酸钠苯基）咪唑-2-亚基]氯化金（I）（C4）以及各自配体的抗菌性能。处理后的生存能力通过直接平板计数法测定。C1和C3表现出的杀菌活性与硝酸银相当。
