Yan Weining, Bläsius Felix, Wahl Tabea, Hildebrand Frank, Balmayor Elizabeth Rosado, Greven Johannes, Horst Klemens
Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Germany.
Experimental Orthopaedics and Trauma Surgery, Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Germany.
PLoS One. 2024 Aug 1;19(8):e0308228. doi: 10.1371/journal.pone.0308228. eCollection 2024.
Chest injury is an important factor regarding the prognosis of patients with polytrauma (PT), and the rapid diagnosis of chest injury is of utmost importance. Therefore, the current study focused on patients' physiology and laboratory findings to quickly identify PT patients with chest injury.
Data on 64 PT patients treated at a trauma center level I between June 2020 and August 2021 were retrospectively collected. The patients were divided into a PT group without chest injury (Group A) and a PT group including chest injury (Group B). The relationship between chest injury and the patients' baseline characteristics and biochemical markers was analyzed.
Heart rate, respiration rate, Sequential Organ Failure Assessment (SOFA) score, glutamate oxaloacetate aminotransferase (GOT), glutamate pyruvate transaminase (GPT), creatine kinase MB (CK-MB), leucocytes, hemoglobin (Hb), platelets, urine output, lactate, and lactate dehydrogenase (LDH) in groups A and B exhibited statistically significant differences at certain time points. Multifactorial analysis showed that blood LDH levels at admission were associated with chest injury (P = 0.039, CI 95% 1.001, 1.022).
LDH may be a promising indicator for screening for the presence of chest injury in patients with severe polytrauma.
胸部损伤是影响多发伤（PT）患者预后的重要因素，快速诊断胸部损伤至关重要。因此，本研究聚焦于患者的生理状况和实验室检查结果，以快速识别合并胸部损伤的多发伤患者。
回顾性收集2020年6月至2021年8月期间在某一级创伤中心接受治疗的64例多发伤患者的数据。将患者分为无胸部损伤的多发伤组（A组）和合并胸部损伤的多发伤组（B组）。分析胸部损伤与患者基线特征及生化标志物之间的关系。
A组和B组在某些时间点的心率、呼吸频率、序贯器官衰竭评估（SOFA）评分、谷草转氨酶（GOT）、谷丙转氨酶（GPT）、肌酸激酶同工酶（CK-MB）、白细胞、血红蛋白（Hb）、血小板、尿量、乳酸及乳酸脱氢酶（LDH）存在统计学显著差异。多因素分析显示，入院时血LDH水平与胸部损伤相关（P = 0.039，95%置信区间1.001，1.022）。
LDH可能是筛查严重多发伤患者胸部损伤的一个有前景的指标。
