Universidade Federal do Rio Grande do Sul Faculdade de Odontologia, Rua Ramiro Barcelos, 2492, sala 503 CEP: 90035-003, Santana, Porto Alegre RS, Brazil
Med Oral Patol Oral Cir Bucal. 2024 Sep 1;29(5):e591-e597. doi: 10.4317/medoral.26501.
This systematic review aimed to incorporate published data regarding synchronous cemento-ossifying fibromas (COF), with an analysis of their demographic and clinicopathological characteristics.
Case reports and case series of synchronous COF were searched in PubMed, Web of Science, Scopus, EMBASE, and LILACS according to the PRISMA (2020) statement. Also, a manual search was carried out and the grey literature was assessed. A descriptive statistical analysis was performed.
Nineteen studies comprising 20 cases of synchronous COF were included. The mean age at diagnosis was 35 years (±13.8), with a predominance of female patients (n=12/60%). In 13 cases (65%) the mandible and the maxilla were affected simultaneously. In two cases (10%) first-degree relatives (parents or siblings) had been previously diagnosed with COF. The diagnostic hypotheses were reported in 8 cases (40%), with florid cemento-osseous dysplasia, ameloblastic fibroodontoma, calcifying cystic odontogenic tumor, osteoma and cementoblastoma being cited in the differential diagnosis. Among the cases with details about management (n=17), eleven were treated by surgical enucleation and/or excision (64.7%). Follow-up was provided for 10 cases (50%), with a mean period of 44.7±62.19 months. Recurrence occurred in three of informed cases.
Synchronous manifestation of COF is rare. Female patients around the 3rd decade of life are more commonly affected. Bilateral involvement of the mandible and maxilla is the most common clinical presentation.
本系统评价旨在纳入关于同步骨化性纤维瘤（COF）的已发表数据，并对其人口统计学和临床病理特征进行分析。
根据 PRISMA（2020）声明，在 PubMed、Web of Science、Scopus、EMBASE 和 LILACS 中搜索同步 COF 的病例报告和病例系列。此外，还进行了手动搜索，并评估了灰色文献。进行了描述性统计分析。
共纳入 19 项研究，包括 20 例同步 COF 患者。诊断时的平均年龄为 35 岁（±13.8），女性患者居多（n=12/60%）。13 例（65%）下颌骨和上颌骨同时受累。2 例（10%）一级亲属（父母或兄弟姐妹）曾被诊断为 COF。8 例（40%）报告了诊断假设，在鉴别诊断中提到了骨化性纤维发育不良、成釉细胞纤维牙瘤、牙源性钙化囊性瘤、骨瘤和骨化性牙瘤。在有详细治疗信息的 17 例病例中，11 例采用手术切除（64.7%）。10 例（50%）提供了随访，平均随访时间为 44.7±62.19 个月。报告的 3 例病例复发。
COF 的同步表现较为罕见。女性患者多发生于 30 岁左右。下颌骨和上颌骨双侧受累是最常见的临床表现。
