HIV 相关的免疫检查点与胰岛β细胞功能障碍。
Immune checkpoints and pancreatic beta cell dysfunction in HIV.
机构信息
Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
AIDS. 2024 Sep 1;38(11):1725-1727. doi: 10.1097/QAD.0000000000003932. Epub 2024 Aug 1.
Abstract
We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.
摘要
我们探讨了免疫失调对 HIV 患者胰岛β细胞损伤的影响。通过分析 105 名参与者的样本，我们观察到未经治疗的 HIV 患者的 IL-21 水平较低，免疫检查点水平（如 PD-1、CD27+、CD40+）升高。值得注意的是，可溶性 TIM-3 与改善的β细胞功能呈正相关，与β细胞应激呈负相关，提示其在未经治疗的 HIV 中β细胞保护中的潜在作用。
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