Department of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Chennai 600089, India.
Department of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Chennai 600089, India.
J Stomatol Oral Maxillofac Surg. 2024 Oct;125(5S2):101990. doi: 10.1016/j.jormas.2024.101990. Epub 2024 Jul 30.
Telocytes are interstitial cells widely distributed in the extracellular matrix of numerous tissues distinguished by their long, thin, and moniliform projections. Telocytes have a role in the stimulation of angiogenesis and contribute to the development and progression of fibrosis.
The current study aimed to assess and compare the telocyte distribution in normal mucosa, oral submucous fibrosis (OSF), and OSCC associated with OSF (OSCCOSF).
Formalin-fixed and paraffin-embedded tissue blocks of 30 OSF cases, 15 OSCCOSF cases, and 15 normal oral mucosae were obtained. Immunohistochemical staining was done with antibodies to CD34 to assess the vasculature and telocytes. The mean vascular density (MVD) and mean telocyte density were compared between the groups using the Kruskal-Walli test.
A statistically significant high MVD (3.4 ± 1.22) and mean telocyte density (3.8 ± 1.35) was observed in OSCCOSF cases while it was lowest in advanced OSF cases. MVD was higher in early OSF cases than in normal mucosa.
This study showed a decrease in CD34-positive telocytes in OSF, indicating that telocyte loss promotes the development of fibrosis.Increased angiogenesis coexisted with an increase in telocytes in OSCCOSF.
细长细胞是广泛分布于多种组织细胞外基质中的间质细胞，其特征为长而细的串珠状突起。细长细胞在刺激血管生成方面发挥作用，并有助于纤维化的发生和发展。
本研究旨在评估和比较正常黏膜、口腔黏膜下纤维化（OSF）和与 OSF 相关的口腔鳞状细胞癌（OSCCOSF）中细长细胞的分布。
收集 30 例 OSF、15 例 OSCCOSF 和 15 例正常口腔黏膜的福尔马林固定和石蜡包埋组织块。使用针对 CD34 的免疫组织化学染色来评估血管生成和细长细胞。使用 Kruskal-Wallis 检验比较各组之间的平均血管密度（MVD）和平均细长细胞密度。
OSCCOSF 病例中观察到统计学上显著较高的 MVD（3.4±1.22）和平均细长细胞密度（3.8±1.35），而在晚期 OSF 病例中最低。早期 OSF 病例中的 MVD 高于正常黏膜。
本研究表明 OSF 中 CD34 阳性细长细胞减少，表明细长细胞丢失促进纤维化的发展。OSCCOSF 中存在增加的血管生成与细长细胞增加并存。
