Suc J M, Vernier I, Durand D, Giraud P, Segonds-Modesto A, Sarramon J P
Nephrologie. 1985;6(3):155-8.
Acute renal failure after captopril therapy in patients with transplant artery stenosis is well known. The study of a new observation may stress three particular points: 1) Diagnosis may be difficult just after transplantation in case of initial acute renal failure. 2) Renal function rapidly improved after withdrawing captopril and furosemide; after surgical treatment of the stenosis, a new course of captopril therapy was possible without any decrease of glomerular filtration rate. 3) A critical fall in filtration fraction seems to be the essential mechanism of renal failure, but specific interstitial lesions of the transplant showed on kidney biopsies, might be discussed.
移植肾动脉狭窄患者在接受卡托普利治疗后发生急性肾衰竭是众所周知的。一项新观察性研究可能强调三个特殊要点:1)在移植术后初期发生急性肾衰竭时,诊断可能困难。2)停用卡托普利和呋塞米后肾功能迅速改善;在对狭窄进行手术治疗后,可重新开始卡托普利治疗,而肾小球滤过率无任何下降。3)滤过分数的严重下降似乎是肾衰竭的基本机制,但对于肾活检显示的移植肾特异性间质病变,可能存在争议。