Division of Immunology, Boston Children's Hospital, Harvard Medical School, Fegan Building 6th Floor, Boston, MA 02115, USA.
Division of Immunology, Boston Children's Hospital, Harvard Medical School, 1 Blackfan Circle, Karp Building 10th Floor, Boston, MA 02115, USA.
Clin Lab Med. 2024 Sep;44(3):479-493. doi: 10.1016/j.cll.2024.04.009. Epub 2024 Jun 8.
There are approximately 500 congenital disorders that impair immune cell development and/or function. Patients with these disorders may present with a wide range of symptoms, including increased susceptibility to infection, autoimmunity, autoinflammation, lymphoproliferation, and/or atopy. Flow cytometry-based immune phenotyping of T and B lymphocytes plays an essential role in the evaluation of patients with these presentations. In this review, we describe the clinical utility of flow cytometry as part of a comprehensive evaluation of immune function and how this testing may be used as a diagnostic tool to identify underlying aberrant immune pathways, monitor disease activity, and assess infection risk.
大约有 500 种先天性疾病会损害免疫细胞的发育和/或功能。这些疾病的患者可能表现出多种症状，包括易感染、自身免疫、自身炎症、淋巴增生和/或过敏。基于流式细胞术的 T 和 B 淋巴细胞免疫表型分析在评估这些表现的患者中起着至关重要的作用。在这篇综述中，我们描述了流式细胞术作为全面评估免疫功能的一部分的临床应用，以及如何将这种检测用作诊断工具来识别潜在的异常免疫途径、监测疾病活动和评估感染风险。
