Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-8548, USA.
Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Adv Surg. 2024 Sep;58(1):223-234. doi: 10.1016/j.yasu.2024.04.013. Epub 2024 May 22.
Historically, stage IV melanoma carried a dismal prognosis and surgical resection was the only potential treatment offering long-term survival or palliation of symptomatic disease. With modern systemic therapies that can provide durable disease control for many patients with metastatic disease, we are actively redefining the role of surgery in metastatic melanoma. Contemporary treatment strategies can employ surgical resection in the upfront setting followed by adjuvant therapy, or used in tailored approach following systemic therapy. The combination of surgical resection and modern therapies has been associated with good long-term survival.
从历史上看，IV 期黑色素瘤预后极差，手术切除是唯一可能提供长期生存或缓解症状性疾病的治疗方法。随着现代系统治疗方法可以为许多转移性疾病患者提供持久的疾病控制，我们正在积极重新定义手术在转移性黑色素瘤中的作用。当代治疗策略可以在初始治疗中采用手术切除，然后进行辅助治疗，或者在系统治疗后采用个体化治疗方法。手术切除与现代治疗方法的结合已与良好的长期生存相关。
