在急性单纯疱疹病毒感染期间，培养的人类神经细胞会积累一种热休克蛋白。
Cultured human neural cells accumulate a heat-shock protein during acute herpes simplex virus infection.
作者信息
Kennedy P G, LaThangue N B, Chan W L, Clements G B
出版信息
Neurosci Lett. 1985 Nov 11;61(3):321-6. doi: 10.1016/0304-3940(85)90484-7.
PMID:3909005
Abstract
Herpes simplex virus-1 (HSV-1) infection of cultured human neural cells causes the accumulation of a host cell-encoded nuclear protein identified as a 57,000 mol.wt. stress protein by monoclonal antibody TI56. This protein is cell cycle-related in fibroblast, may mediate host cell control during HSV infection and could play a role in the regulation of HSV latency.
摘要
单纯疱疹病毒1型（HSV-1）感染培养的人神经细胞会导致一种宿主细胞编码的核蛋白积累，该蛋白被单克隆抗体TI56鉴定为分子量57,000的应激蛋白。这种蛋白在成纤维细胞中与细胞周期相关，可能在HSV感染期间介导宿主细胞控制，并可能在HSV潜伏的调节中发挥作用。
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