Xue Binghui, Liu Yuan, Tian Ye, Yin Panchao
State Key Laboratory of Luminescent Materials and Devices & South China Advanced Institute for Soft Matter Science and Technology, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou, China.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, P.R. China.
Nat Commun. 2024 Aug 1;15(1):6502. doi: 10.1038/s41467-024-50859-z.
The rod-like viruses show anomalously rapid diffusion in bio-tissue networks originated from the rotation-facilitated transportation; however, the experimental investigation of the correlation of the rotational and translational dynamics is still in blank. Herein, typical rod-like and spherical gold nanoparticles (NPs) are dispersed in the classical Tetra-PEG gels, respectively, as model systems for light scattering studies. The contributions from translational and rotational diffusive dynamics, and network fluctuation dynamics can be well-resolved and the stretch exponent of rotational dynamics at 0.25 is proven to be the fingerprint for the coupled rotational and translational dynamics of nanorods. The rotation facilitated re-orientation finally leads to the fast transportation of nanorods. The discoveries are confirmed to be valid for rod-like biomacromolecule systems by studying the diffusive dynamics of Tobacco mosaic virus in gels. The work can be inspiring for the development of protocols to prevent infection of microorganism and regulate the transportation of nano-medicines.
杆状病毒在由旋转促进运输产生的生物组织网络中表现出异常快速的扩散；然而，对旋转和平移动力学相关性的实验研究仍处于空白。在此，典型的杆状和球形金纳米颗粒（NPs）分别分散在经典的四聚乙二醇凝胶中，作为光散射研究的模型系统。平动和转动扩散动力学以及网络涨落动力学的贡献可以得到很好的分辨，并且转动动力学在0.25时的伸展指数被证明是纳米棒耦合转动和平移动力学的指纹。旋转促进的重新定向最终导致纳米棒的快速运输。通过研究烟草花叶病毒在凝胶中的扩散动力学，证实这些发现对于杆状生物大分子系统是有效的。这项工作对于开发预防微生物感染和调节纳米药物运输的方案可能具有启发性。
