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狨猴无创嗅觉刺激功能磁共振成像系统的研制。

Development of a noninvasive olfactory stimulation fMRI system in marmosets.

作者信息

Yurimoto Terumi, Seki Fumiko, Yamada Akihiro, Okajima Junnosuke, Yambe Tomoyuki, Takewa Yoshiaki, Kamioka Michiko, Inoue Takashi, Inoue Yusuke, Sasaki Erika

机构信息

Department of Marmoset Biology and Medicine, Central Institute for Experimental Medicine and Life Science, Kawasaki, Japan.

Bioimaging Center, Central Institute for Experimental Medicine and Life Science, Kawasaki, Japan.

出版信息

Sci Rep. 2024 Aug 1;14(1):17830. doi: 10.1038/s41598-024-68508-2.

DOI:10.1038/s41598-024-68508-2
PMID:39090331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11294473/
Abstract

Olfactory dysfunction is associated with aging and the earliest stages of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases; it is thought to be an early biomarker of cognitive decline. In marmosets, a small non-human primate model used in brain research, olfactory pathway activity during olfactory stimulation has not been well studied because of the difficulty in clearly switching olfactory stimuli inside a narrow MRI. Here, we developed an olfactory-stimulated fMRI system using a small-aperture MRI machine. The olfactory presentation system consisted of two tubes, one for supply and one for suction of olfactory stimulants and a balloon valve. A balloon valve installed in the air supply tube controlled the presentation of the olfactory stimulant, which enabled sharp olfactory stimulation within MRI, such as 30 s of stimulation repeated five times at five-minute intervals. The olfactory stimulation system was validated in vivo and in a simulated system. fMRI analysis showed a rapid increase in signal values within 30 s of olfactory stimulation in eight regions related to the sense of smell. As these regions include those associated with Alzheimer's and Parkinson's diseases, olfactory stimulation fMRI may be useful in clarifying the relationship between olfactory dysfunction and dementia in non-human primates.

摘要

嗅觉功能障碍与衰老以及神经退行性疾病（如阿尔茨海默病和帕金森病）的早期阶段相关；它被认为是认知衰退的早期生物标志物。在狨猴（一种用于脑研究的小型非人类灵长类动物模型）中，由于在狭窄的磁共振成像（MRI）内难以清晰切换嗅觉刺激，嗅觉刺激期间的嗅觉通路活动尚未得到充分研究。在此，我们使用小型孔径MRI机器开发了一种嗅觉刺激功能磁共振成像（fMRI）系统。嗅觉呈现系统由两根管子组成，一根用于供应，一根用于抽吸嗅觉刺激物以及一个球囊阀。安装在空气供应管中的球囊阀控制嗅觉刺激物的呈现，这使得在MRI内能够进行精确的嗅觉刺激，例如以5分钟的间隔重复5次30秒的刺激。该嗅觉刺激系统在体内和模拟系统中均得到了验证。功能磁共振成像分析显示，在与嗅觉相关的八个区域中，嗅觉刺激30秒内信号值迅速增加。由于这些区域包括与阿尔茨海默病和帕金森病相关的区域，嗅觉刺激功能磁共振成像可能有助于阐明非人类灵长类动物嗅觉功能障碍与痴呆之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/bae5a9d19161/41598_2024_68508_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/7fc62f531e67/41598_2024_68508_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/7fba019869c5/41598_2024_68508_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/bae5a9d19161/41598_2024_68508_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/7fc62f531e67/41598_2024_68508_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/1dd1038b757d/41598_2024_68508_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/e8e64297cc3e/41598_2024_68508_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/7234890533c2/41598_2024_68508_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/1ccc3159441a/41598_2024_68508_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/40e7b2a5f362/41598_2024_68508_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/7fba019869c5/41598_2024_68508_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4170/11294473/bae5a9d19161/41598_2024_68508_Fig8_HTML.jpg

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本文引用的文献

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Neural Representation of Intraoral Olfactory and Gustatory Signals by the Mediodorsal Thalamus in Alert Rats.清醒大鼠中背内侧丘脑对口腔内嗅觉和味觉信号的神经表征
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MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb.MRI 示踪技术揭示了连接嗅上皮和嗅球的人类嗅神经图谱。
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Potential trade-off between olfactory and visual discrimination learning in common marmosets (Callithrix jacchus): Implications for the assessment of age-related cognitive decline.
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