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使用位置相关的图像去模糊和衰减去除来校正定向暗场X射线成像伪影。

Correcting directional dark field x-ray imaging artefacts using position dependent image deblurring and attenuation removal.

作者信息

Croughan Michelle K, Paganin David M, Alloo Samantha J, Ahlers Jannis N, How Ying Ying, Harker Stephanie A, Morgan Kaye S

机构信息

Monash University, School of Physics and Astronomy, Melbourne, 3800, Australia.

University of Canterbury, School of Physical and Chemical Sciences, Christchurch, 8041, New Zealand.

出版信息

Sci Rep. 2024 Aug 1;14(1):17807. doi: 10.1038/s41598-024-68659-2.

DOI:10.1038/s41598-024-68659-2
PMID:39090344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11294358/
Abstract

In recent years, a novel x-ray imaging modality has emerged that reveals unresolved sample microstructure via a "dark-field image", which provides complementary information to conventional "bright-field" images, such as attenuation and phase-contrast modalities. This x-ray dark-field signal is produced by unresolved microstructures scattering the x-ray beam resulting in localised image blur. Dark-field retrieval techniques extract this blur to reconstruct a dark-field image. Unfortunately, the presence of non-dark-field blur such as source-size blur or the detector point-spread-function can affect the dark-field retrieval as they also blur the experimental image. In addition, dark-field images can be degraded by the artefacts induced by large intensity gradients from attenuation and propagation-based phase contrast, particularly around sample edges. By measuring any non-dark-field blurring across the image plane and removing it from experimental images, as well as removing attenuation and propagation-based phase contrast, we show that a directional dark-field image can be retrieved with fewer artefacts and more consistent quantitative measures. We present the details of these corrections and provide "before and after" directional dark-field images of samples imaged at a synchrotron source. This paper utilises single-grid directional dark-field imaging, but these corrections have the potential to be broadly applied to other x-ray imaging techniques.

摘要

近年来,一种新型的X射线成像方式出现了,它通过“暗场图像”揭示未解析的样品微观结构,该图像为传统的“明场”图像(如衰减和相衬成像方式)提供了补充信息。这种X射线暗场信号是由未解析的微观结构散射X射线束产生的,导致局部图像模糊。暗场检索技术提取这种模糊来重建暗场图像。不幸的是,诸如源尺寸模糊或探测器点扩散函数等非暗场模糊的存在会影响暗场检索,因为它们也会使实验图像模糊。此外,暗场图像会因衰减和基于传播的相衬产生的大强度梯度所引起的伪影而退化,特别是在样品边缘周围。通过测量图像平面上的任何非暗场模糊并从实验图像中去除它,以及去除基于衰减和传播的相衬,我们表明可以检索到具有更少伪影和更一致定量测量的定向暗场图像。我们展示了这些校正的细节,并提供了在同步辐射源成像的样品的“校正前”和“校正后”定向暗场图像。本文采用单网格定向暗场成像,但这些校正有可能广泛应用于其他X射线成像技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/5862f16cfc02/41598_2024_68659_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/a4f060e58d74/41598_2024_68659_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/c51e89c61628/41598_2024_68659_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/136667f94c39/41598_2024_68659_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/5963d0d7fee3/41598_2024_68659_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/781a5c585a91/41598_2024_68659_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/d65b987115c6/41598_2024_68659_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/5862f16cfc02/41598_2024_68659_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/a4f060e58d74/41598_2024_68659_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/c51e89c61628/41598_2024_68659_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/136667f94c39/41598_2024_68659_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/5963d0d7fee3/41598_2024_68659_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/781a5c585a91/41598_2024_68659_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/d65b987115c6/41598_2024_68659_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0303/11294358/5862f16cfc02/41598_2024_68659_Fig7_HTML.jpg

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本文引用的文献

1
Correction for X-Ray Scatter and Detector Crosstalk in Dark-Field Radiography.暗场射线照相术中X射线散射和探测器串扰的校正
IEEE Trans Med Imaging. 2024 Jul;43(7):2646-2656. doi: 10.1109/TMI.2024.3374974. Epub 2024 Jul 1.
2
On the quantification of sample microstructure using single-exposure x-ray dark-field imaging via a single-grid setup.基于单网格设置的单次曝光 X 射线暗场成像对样品微观结构的定量分析。
Sci Rep. 2023 Jul 7;13(1):11001. doi: 10.1038/s41598-023-37334-3.
3
Dark-Field Chest Radiography Outperforms Conventional Chest Radiography for the Diagnosis and Staging of Pulmonary Emphysema.
暗场胸部 X 线摄影术在诊断和分期肺气肿方面优于常规胸部 X 线摄影术。
Invest Radiol. 2023 Nov 1;58(11):775-781. doi: 10.1097/RLI.0000000000000989. Epub 2023 May 26.
4
Directional dark-field retrieval with single-grid x-ray imaging.基于单光栅 X 射线成像的暗场方向重建。
Opt Express. 2023 Mar 27;31(7):11578-11597. doi: 10.1364/OE.480031.
5
Artifacts reduction in high-acutance phase images for X-ray grating interferometry.用于X射线光栅干涉测量的高锐度相位图像中的伪影减少
Opt Express. 2022 Nov 7;30(23):41147-41156. doi: 10.1364/OE.467503.
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X-ray directional dark-field imaging using Unified Modulated Pattern Analysis.基于统一调制模式分析的 X 射线定向暗场成像
PLoS One. 2022 Aug 29;17(8):e0273315. doi: 10.1371/journal.pone.0273315. eCollection 2022.
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Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography.基于相衬层析术的暗场信号对乳腺微钙化的成像。
IEEE Trans Med Imaging. 2022 Nov;41(11):2980-2990. doi: 10.1109/TMI.2022.3175924. Epub 2022 Oct 27.
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Quantifying the x-ray dark-field signal in single-grid imaging.单网格成像中X射线暗场信号的量化
Opt Express. 2022 Mar 28;30(7):10899-10918. doi: 10.1364/OE.451834.
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Dark-Field Microscopy: Recent Advances in Accurate Analysis and Emerging Applications.暗视野显微镜:精确分析的最新进展与新兴应用
Anal Chem. 2021 Mar 23;93(11):4707-4726. doi: 10.1021/acs.analchem.0c04390. Epub 2021 Feb 23.
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Assessment of the additional clinical potential of X-ray dark-field imaging for breast cancer in a preclinical setup.在临床前设置中评估X射线暗场成像对乳腺癌的额外临床潜力。
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