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[肺部疾病中的性别医学]

[Gender medicine in lung diseases].

作者信息

Klotz Laura V, Deissner Henrike, Eichhorn Florian

机构信息

Klinik für Thoraxchirurgie, Thoraxklinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland.

出版信息

Chirurgie (Heidelb). 2024 Sep;95(9):730-735. doi: 10.1007/s00104-024-02141-7. Epub 2024 Aug 1.

Abstract

Gender-specific differences in the diagnostics and treatment must be considered for various lung diseases. In the case of pneumothorax, in addition to differences in etiology there are also relevant differences in treatment and recurrence rates between men and women. For example, to achieve low recurrence rates catamenial pneumothorax requires interdisciplinary collaboration with gynecology. The incidence of lung cancer has equalized in recent years and in addition, various gender-specific prognostic factors have become relevant. Several meta-analyses have identified female gender as a positive prognostic factor for lung cancer, in addition to the higher prevalence of various driver mutations in women. In current trials of multimodal treatment for lung cancer, gender differences in tolerability and patient outcome are already apparent. In subgroup analyses better event-free survival was observed in women, although immune-mediated adverse events were more common in women.

摘要

对于各种肺部疾病,必须考虑诊断和治疗中的性别差异。在气胸方面,除了病因不同外,男性和女性在治疗和复发率方面也存在相关差异。例如,为了实现低复发率,月经性气胸需要与妇科进行跨学科合作。近年来肺癌的发病率已经趋于平衡,此外,各种性别特异性的预后因素也变得至关重要。多项荟萃分析已将女性性别确定为肺癌的一个积极预后因素,此外女性中各种驱动基因突变的患病率更高。在目前的肺癌多模式治疗试验中,耐受性和患者预后方面的性别差异已经很明显。在亚组分析中,女性的无事件生存期更好,尽管免疫介导的不良事件在女性中更常见。

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