South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
Bull Exp Biol Med. 2024 Jun;177(2):278-280. doi: 10.1007/s10517-024-06173-1. Epub 2024 Aug 1.
An additional microscopic diagnostic sign has been identified for verification of asphyxial type of drowning. In white non-linear male rats (age 2 months) subjected to free drowning, significant hyperplasia of argyrophilic and morphofunctional activity of serotonin-containing APUD-cells of the laryngeal mucosa were revealed under conditions of acute anoxia in comparison with the intact control. These changes promote the development of laryngospasm, which prevents water penetration into the airways and lungs in asphyxial type of drowning. The presence of statistically significant hyperplasia of argyrophilic and morphofunctional activity of serotonin-containing APUD-cells of the laryngeal mucosa under conditions of acute anoxia can be used as an additional diagnostic criterion for asphyxial type of drowning in experimental studies.
已经确定了一个额外的微观诊断标志，用于验证窒息性溺水的类型。在暴露于自由溺水的白色非线性雄性大鼠（2 月龄）中，与完整对照组相比，在急性缺氧条件下，喉黏膜中含银和含 5-羟色胺的 APUD 细胞的增生和形态功能活性显著增加。这些变化促进了喉痉挛的发展，从而防止了窒息性溺水时水进入气道和肺部。在急性缺氧条件下，喉黏膜中含银和含 5-羟色胺的 APUD 细胞的增生和形态功能活性具有统计学意义，可以作为实验研究中窒息性溺水的附加诊断标准。
