阴茎鳞状细胞癌中与三级淋巴结构相关的预后模型。
A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma.
机构信息
Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China.
Department of Urology, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.
出版信息
BMC Urol. 2024 Aug 2;24(1):165. doi: 10.1186/s12894-024-01532-6.
BACKGROUND
We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).
METHODS
We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.
RESULT
BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).
CONCLUSION
TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.
背景
我们研究了三级淋巴结构 (TLS) 作为预测阴茎鳞癌预后的标志物的可行性。
方法
我们回顾性地收集了 83 例阴茎鳞癌患者的数据。对 TLS 密度进行 H&E 染色切片评估。此外，分析了临床参数，使用 Kaplan-Meier 生存曲线评估这些参数对总生存 (OS) 的预后价值，并使用 Cox 多因素设计列线图分析评估影响因素的预后价值。
结果
BMI、T、N 和 M 在有或没有三级淋巴结构的生存曲线中均有显著意义。BMI、T、N、M 和 TLS 用于构建阴茎鳞癌的预后模型，预测准确性达到共识的 0.884(0.835-0.932)，决策一致性达到 0.581(0.508-0.655)。
结论
TLS 可能是阴茎鳞癌的一个阳性预后因素，BMI、T、N 和 M 的联合可以更好地评估患者的预后。
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