Kwagala Claire, Munube Deogratias, Abbo Catherine, Muhwezi Wilson Winstons, Mwesiga Emmanuel Kiiza
Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7062, Kampala, Uganda.
Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Child Adolesc Psychiatry Ment Health. 2024 Aug 1;18(1):94. doi: 10.1186/s13034-024-00790-4.
Opioid use disorder (OUD) among adolescents with sickle cell disease (SCD) patients increases their risk of complications from sickle cell disease, such as infections, stroke, acute chest syndrome, sudden death, and organ failure. This negatively impacts families, communities, the national health system, and the economy. This study aimed to determine the prevalence and factors associated with opioid use disorder among adolescents with SCD at Mulago Hospital Uganda.
This study was carried out at the Sickle Cell Clinic of Mulago Hospital, the national referral hospital in Uganda. The study participants were adolescents aged 10 to 19 years. Following informed consent/ assent, a sociodemographic questionnaire, the WHO Alcohol, Smoking and Substance Involvement Screening Test - Young (ASSIST-Y), the Beck Depression Inventory-II (BDI II), and Generalized Anxiety Disorder - 7 (GAD-7) questionnaires were used to collect data. Data was entered in EpiInfo and analyzed in STATA 15.
The prevalence of opioid use disorder was 5.3%. The significant risk factor was increasing depressive score AOR: 1.11(95% CI: 1.01-1.22, p = 0.035), while living with a family was protective against opioid use disorders AOR: 0.01; (95% CI: 0.0004, 0.27, p = 0.007).
There was a significant problem of OUD among adolescents with SCD. There is, therefore, needed to integrate screening of OUD and mental illnesses like depression among adolescents with SCD and to emphasize the importance of family support in their care.
镰状细胞病（SCD）青少年患者中的阿片类药物使用障碍（OUD）会增加他们患镰状细胞病并发症的风险，如感染、中风、急性胸综合征、猝死和器官衰竭。这会对家庭、社区、国家卫生系统和经济产生负面影响。本研究旨在确定乌干达穆拉戈医院SCD青少年中阿片类药物使用障碍的患病率及相关因素。
本研究在乌干达国家转诊医院穆拉戈医院的镰状细胞诊所进行。研究参与者为10至19岁的青少年。在获得知情同意/同意后，使用社会人口学问卷、世界卫生组织酒精、吸烟和物质使用筛查测试-青年版（ASSIST-Y）、贝克抑郁量表第二版（BDI II）和广泛性焦虑障碍-7（GAD-7）问卷收集数据。数据录入EpiInfo并在STATA 15中进行分析。
阿片类药物使用障碍的患病率为5.3%。显著的风险因素是抑郁评分增加，调整后比值比（AOR）：1.11（95%置信区间：1.01-1.22，p = 0.035），而与家人同住对阿片类药物使用障碍有保护作用，AOR：0.01；（95%置信区间：0.0004，0.27，p = 0.007）。
SCD青少年中存在严重的OUD问题。因此，需要对SCD青少年进行OUD和抑郁症等精神疾病的筛查，并强调家庭支持在他们护理中的重要性。
