Barnekow Tiana, Peters Claudia, Dulon Madeleine, Nienhaus Albert
Competence Centre for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), University Medical Centre Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.
Department of Occupational Medicine, Hazardous Substances and Public Health, Institution for Statutory Accident Insurance and Prevention in the Healthcare and Welfare Services, 22089, Hamburg, Germany.
J Occup Med Toxicol. 2024 Aug 1;19(1):32. doi: 10.1186/s12995-024-00431-8.
The underlying mechanisms of post-COVID syndrome (PCS) are still not fully understood. While pre-existing conditions have been described as a risk factor for severe PCS in the general population, data specific to different occupational groups in this context is lacking. This study aimed to investigate the impact of pre-existing conditions on severe post-COVID syndrome among the occupational group of healthcare and social services employees.
Baseline data from a longitudinal, observational study were analysed. In February 2021, health workers who had a COVID-19 infection in 2020 were surveyed about sequelae of the infection. Factors influencing severe PCS with at least one persistent symptom categorised as severe were subjected to a multivariate logistic regression analysis.
Of a total of 2,053 participants, 21.5% had severe PCS. Underlying respiratory (OR 1.94; CI 1.44-2.61), cardiovascular (OR 1.35; CI 1.04-1.77) and urogenital (OR 1.79; CI 1.10-2.91) disease were risk factors for severe PCS overall. Respiratory and mental illnesses had a statistically significant impact on persistent fatigue/exhaustion, concentration/memory difficulties and shortness of breath categorised as severe. Urogenital disease was associated with severe fatigue/exhaustion. Other significant risk factors for severe PCS were female sex, smoking, physical exercise and hospitalisation due to COVID-19 infection.
Workers in healthcare and social services with pre-existing conditions may face a higher risk of developing severe PCS. Additional analyses performed as part of the longitudinal study will show if and how this result changes over time.
新冠后综合征（PCS）的潜在机制仍未完全明确。虽然已有研究表明，基础疾病是普通人群中发生严重PCS的一个风险因素，但在此背景下针对不同职业群体的具体数据尚缺。本研究旨在调查基础疾病对医护及社会服务职业群体中严重新冠后综合征的影响。
对一项纵向观察性研究的基线数据进行分析。2021年2月，对2020年感染过新冠病毒的医护人员就感染后遗症进行了调查。对影响严重PCS（至少有一种持续症状被归类为严重症状）的因素进行多因素逻辑回归分析。
在总共2053名参与者中，21.5%患有严重PCS。基础呼吸系统疾病（比值比[OR] 1.94；可信区间[CI] 1.44 - 2.61）、心血管疾病（OR 1.35；CI 1.04 - 1.77）和泌尿生殖系统疾病（OR 1.79；CI 1.10 - 2.91）是总体严重PCS的风险因素。呼吸系统疾病和精神疾病对归类为严重的持续疲劳/疲惫、注意力/记忆力障碍和呼吸急促有统计学显著影响。泌尿生殖系统疾病与严重疲劳/疲惫有关。严重PCS的其他显著风险因素包括女性、吸烟、体育锻炼以及因新冠病毒感染住院。
有基础疾病的医护及社会服务工作者可能面临更高的发生严重PCS的风险。作为纵向研究一部分所进行的进一步分析将表明这一结果是否以及如何随时间变化。
