[Metabolism of antipyrine in man].
作者信息
Pautet F, Barret R, Daudon M, Mathian B
出版信息
Pathol Biol (Paris). 1985 Sep;33(7):777-80.
PMID:3909077
Abstract
Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite fate of this drug is not fully understood. A new metabolite pathway including a ring opening seems possible.
摘要
相似文献
1
[Metabolism of antipyrine in man].
Pathol Biol (Paris). 1985 Sep;33(7):777-80.
2
[Effect of the diethylamide of nicotinic acid (cordiamine) on the hydroxylating function of the liver].[烟酸二乙胺（可拉明）对肝脏羟化功能的影响]
Farmakol Toksikol. 1989 Jul-Aug;52(4):56-9.
3
Effect of silybin on the hepatic microsomal drug-metabolising enzyme system in the rat.水飞蓟宾对大鼠肝脏微粒体药物代谢酶系统的影响。
Arzneimittelforschung. 1974 Dec;24(12):1986-8.
4
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes.细胞色素P450 3A4酶在人肝微粒体中美沙酮N-去甲基化过程中的作用。
Chem Res Toxicol. 1996 Mar;9(2):365-73. doi: 10.1021/tx950116m.
5
6
Effects of 5-fluorouracil on drug-metabolizing enzymes in the rat.5-氟尿嘧啶对大鼠药物代谢酶的影响。
Cancer Res. 1974 May;34(5):927-31.
7
Effect of phenobarbital and spironolactone treatment on the oxidative metabolism of antipyrine by rat liver microsomes.苯巴比妥和螺内酯治疗对大鼠肝微粒体中安替比林氧化代谢的影响。
Pol J Pharmacol. 2001 Jan-Feb;53(1):11-9.
8
Antipyrine metabolism in the rat by three hepatic monooxygenases.大鼠体内三种肝脏单加氧酶参与的安替比林代谢
Life Sci. 1980 Jun 9;26(23):1977-83. doi: 10.1016/0024-3205(80)90629-3.
9
Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats.克拉霉素及其代谢产物对大鼠肝微粒体混合功能氧化酶系统的影响。
Drug Metab Dispos. 1993 Mar-Apr;21(2):358-63.
10
Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation.安替比林作为人类氧化药物代谢的探针：催化4-羟基安替比林、3-羟甲基安替比林和去甲安替比林形成的细胞色素P450酶的鉴定。
Clin Pharmacol Ther. 1996 Jun;59(6):613-23. doi: 10.1016/S0009-9236(96)90001-6.
Zotero 插件