Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Prosthodontics, Gerodontology and Oral Rehabilitation, Osaka University Graduate School of Dentistry, Suita, Japan.
Geriatr Gerontol Int. 2024 Sep;24(9):898-903. doi: 10.1111/ggi.14951. Epub 2024 Aug 1.
Vitamin D (VD) affects skeletal muscles. The high prevalence of VD deficiency in Japan may lead to decreased skeletal muscle mass and strength, increasing the prevalence of sarcopenia. Therefore, we aimed to investigate the association between serum VD levels and skeletal muscle indices in a Japanese community-dwelling older population.
We extracted data from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study. We analyzed the data for participants in the 70s and 90s age groups. Skeletal mass index (SMI) using bioimpedance analysis, grip strength, walking speed, and serum VD levels using 25-hydroxyvitamin D [25(OH)D] were measured.
We analyzed the data of 310 participants in their 70s and 48 in their 90s. Mean serum 25(OH)D levels were 21.6 ± 5.0 ng/mL in the 70s group and 23.4 ± 9.1 ng/mL in the 90s group. In the 70s group, serum 25(OH)D levels correlated with SMI (r = 0.21, P < 0.0001) and grip strength (r = 0.30, P < 0.0001). Serum 25(OH)D levels were independently associated with SMI after adjusting for sex, body mass index, and serum albumin levels. In the 90s group, serum 25(OH)D levels were correlated with SMI (r = 0.29, P = 0.049) and grip strength (r = 0.34, P = 0.018). However, the multivariate analysis showed no independent association between SMI, grip strength, and serum 25(OH)D levels.
In a cross-sectional analysis of an older population, serum VD levels were associated with SMI and grip strength, and this association was more pronounced in the 70s group than in the 90s group. Our results suggest that serum VD levels maintain skeletal muscle mass and grip strength. Geriatr Gerontol Int 2024; 24: 898-903.
维生素 D（VD）会影响骨骼肌。日本 VD 缺乏症的高发率可能导致骨骼肌质量和力量下降，增加肌少症的患病率。因此，我们旨在调查日本社区居住的老年人群中血清 VD 水平与骨骼肌指数之间的关系。
我们从 70 岁、80 岁和 90 岁以上人群研究（SONIC）中提取数据。我们分析了 70 岁和 90 岁年龄组参与者的数据。使用生物电阻抗分析测量骨骼肌指数（SMI）、握力、步行速度和血清 VD 水平（25-羟维生素 D [25（OH）D]）。
我们分析了 310 名 70 多岁和 48 名 90 多岁参与者的数据。70 多岁组的平均血清 25（OH）D 水平为 21.6±5.0ng/ml，90 多岁组为 23.4±9.1ng/ml。在 70 多岁组中，血清 25（OH）D 水平与 SMI（r=0.21，P<0.0001）和握力（r=0.30，P<0.0001）相关。在调整性别、体重指数和血清白蛋白水平后，血清 25（OH）D 水平与 SMI 独立相关。在 90 多岁组中，血清 25（OH）D 水平与 SMI（r=0.29，P=0.049）和握力（r=0.34，P=0.018）相关。然而，多元分析显示 SMI、握力和血清 25（OH）D 水平之间没有独立的关联。
在对老年人群的横断面分析中，血清 VD 水平与 SMI 和握力相关，且在 70 多岁组中的相关性强于 90 多岁组。我们的结果表明，血清 VD 水平维持骨骼肌质量和握力。老年医学与老年病学杂志 2024；24：898-903。
