Mi Weinuo, Zhang Huifeng, Zhang Lina, Li Xingjia, Wang Zhiguo, Sun Yu, Shen Tonggao, Fan Kuanlu, Liu Chao, Xu Shuhang
Department of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China.
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
Sci Rep. 2025 Jan 4;15(1):765. doi: 10.1038/s41598-025-85468-3.
This study aimed to identify the correlation of serum 25(OH)D level with sarcopenia and its components in Chinese elderly aged 65 years and above from rural areas. A total of 368 Chinese elderly aged 65 years and above in rural areas were enrolled. Indicators of muscle mass and strength, including the appendicular skeletal muscle mass (ASM), skeletal muscle index (SMI) and hand grip strength (HGS) were measured. Physical performance was assessed by the Short Physical Performance Battery (SPPB). Serum 25(OH)D levels were measured using the liquid chromatography with tandem mass spectrometry. Correlations of serum 25(OH)D level with sarcopenia and its components in Chinese elderly were identified by the binary logistic regression and linear regression analyses. The median serum 25(OH)D level was 34.80 ng/ml, and significantly higher in men than in women (40.70 ng/ml vs. 27.30 ng/ml). The prevalence of sarcopenia in our cohort was 21.5%, and higher in men than in women (29.4% vs. 10.8%). The serum 25(OH)D level was not correlated with sarcopenia, HGS and SPPB score in either male or female elderly. Positive correlations of age with sarcopenia, low HGS and low SPPB score were observed in male elderly, while significant correlations were not observed in females. Correlation analyses of sarcopenia components revealed that age was negatively correlated with SMI and gait speed in male elderly, but negatively correlated with the gait speed and positively correlated with the time to complete 5 sit-to-stand movements in female elderly. In conclusion, rural Chinese elderly have relatively high vitamin D level and prevalence of sarcopenia. Age but not serum 25(OH)D level is significantly correlated with sarcopenia in vitamin D sufficient male elderly.
本研究旨在确定中国农村65岁及以上老年人血清25(OH)D水平与肌肉减少症及其组成部分之间的相关性。共纳入368名中国农村65岁及以上老年人。测量肌肉质量和力量指标，包括四肢骨骼肌质量（ASM）、骨骼肌指数（SMI）和握力（HGS）。通过简短体能状况量表（SPPB）评估身体功能。采用液相色谱串联质谱法测量血清25(OH)D水平。通过二元逻辑回归和线性回归分析确定中国老年人血清25(OH)D水平与肌肉减少症及其组成部分之间的相关性。血清25(OH)D水平中位数为34.80 ng/ml，男性显著高于女性（40.70 ng/ml对27.30 ng/ml）。我们队列中肌肉减少症的患病率为21.5%，男性高于女性（29.4%对10.8%）。血清25(OH)D水平与男性或女性老年人的肌肉减少症、HGS和SPPB评分均无相关性。在男性老年人中观察到年龄与肌肉减少症、低HGS和低SPPB评分呈正相关，而在女性中未观察到显著相关性。肌肉减少症组成部分的相关分析显示，年龄与男性老年人的SMI和步速呈负相关，但与女性老年人的步速呈负相关，与完成5次坐立运动的时间呈正相关。总之，中国农村老年人维生素D水平和肌肉减少症患病率相对较高。在维生素D充足的男性老年人中，与肌肉减少症显著相关的是年龄而非血清25(OH)D水平。
