Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.
HLA. 2024 Aug;104(2):e15616. doi: 10.1111/tan.15616.
Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB103:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB111:01, DRB302:02, DQA105:05, DQB103:01 or DRB111:04, DRB302:02, DQA105:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.
大疱性类天疱疮（BP）虽然是一种罕见疾病，但却是最常见的皮下自身免疫性疾病。已有报道称，用于 2 型糖尿病的gliptin 类药物与 BP 的发病有关。为了确定可能反映意大利人群中对 BP 更高易感性的 HLA 等位基因，我们分析了 30 名特发性大疱性类天疱疮（IBP）患者和 86 名gliptin 相关 BP（GABP）患者。发现 HLA-DQB103:01 等位基因与 IBP 和 GABP 患者显著相关。值得注意的是，IBP 和 GABP 均与以下单倍型之一显著相关：DRB111:01、DRB302:02、DQA105:05、DQB103:01 或 DRB111:04、DRB302:02、DQA105:05 和 DQB1*03:01。这些数据首次确定了意大利人群中 BP 易感性的潜在标志物，尤其是与gliptin 摄入相关时。
