Kulla Artenisa, Mirza Basil, Campbell Kevin James
College of Medicine, University of Florida, Gainesville, FL, USA.
Department of Urology, College of Medicine, University of Florida, Gainesville, FL, USA.
J Hum Reprod Sci. 2024 Apr-Jun;17(2):133-135. doi: 10.4103/jhrs.jhrs_28_24. Epub 2024 May 28.
Limited research exists on the mechanisms underlying asthenozoospermia associated with acquired ciliary dyskinesia. Primary ciliary dyskinesia links respiratory pathology with infertility and provides a basis for a potential mechanism. The aetiology of asthenozoospermia is often unclear and may be secondary to direct or indirect effects on sperm motility. Here, we report a case - with a brief clinical review - of recovering sperm motility after diagnosis of complete asthenozoospermia coinciding with resolution of chronic respiratory infections. The patient is a 36-year-old male, with initial semen analysis demonstrating 100% immotile sperm. Following the resolution of chronic respiratory infection, subsequent analysis demonstrated functional improvement with 76 million sperm/mL, 8% progressive motility and 4% strict morphology. Our case reinforces a potentially underappreciated role of environmental risk factors in infertility, with a focus on the patient's history of infections and other risk factors for acquired ciliary dyskinesia, which should be kept in mind when treating patients with asthenozoospermia.
关于与获得性纤毛运动障碍相关的弱精子症的潜在机制，现有研究有限。原发性纤毛运动障碍将呼吸道病理与不孕症联系起来，并为潜在机制提供了依据。弱精子症的病因往往不明，可能是对精子活力直接或间接影响的结果。在此，我们报告一例病例——并进行简要临床回顾——在诊断为完全性弱精子症且慢性呼吸道感染得到缓解后，精子活力恢复。患者为一名36岁男性，初始精液分析显示精子100%不活动。慢性呼吸道感染缓解后，后续分析显示功能改善，精子浓度为7600万/mL，进行性运动精子比例为8%，严格形态精子比例为4%。我们的病例强化了环境危险因素在不孕症中可能未得到充分重视的作用，重点关注患者的感染史和获得性纤毛运动障碍的其他危险因素，在治疗弱精子症患者时应牢记这些因素。
