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3
Human Disseminated Protothecosis: The Skin is the "Window"?人播散性原绿球藻病：皮肤是“窗口”？
Front Immunol. 2022 Jun 14;13:880196. doi: 10.3389/fimmu.2022.880196. eCollection 2022.
4
Efficacy of Cochleated Amphotericin B in Mouse and Human Mucocutaneous Candidiasis.耳蜗内两性霉素 B 在小鼠和人体黏膜念珠菌病中的疗效。
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Fatal Prototheca zopfii Algaemia in a Patient with Acute Lymphoblastic Leukemia: a Case Report.急性淋巴细胞白血病患者致死性小茨藻藻血症：病例报告。
Clin Lab. 2022 Apr 1;68(4). doi: 10.7754/Clin.Lab.2021.210723.
6
Amphotericin B and Other Polyenes-Discovery, Clinical Use, Mode of Action and Drug Resistance.两性霉素B及其他多烯类药物——发现、临床应用、作用机制与耐药性
J Fungi (Basel). 2020 Nov 27;6(4):321. doi: 10.3390/jof6040321.
7
Emergence of Fungal-Like Organisms: Prototheca.真菌样生物体的出现：原绿球藻。
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8
Amphotericin B formulations: a comparative review of efficacy and toxicity.两性霉素 B 制剂：疗效和毒性的比较评价。
Drugs. 2013 Jun;73(9):919-34. doi: 10.1007/s40265-013-0069-4.
9
Protothecosis.原囊菌病。
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用两性霉素B的口服脂质纳米晶制剂MAT2203成功治疗难治性皮肤原壁菌病

Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B.

作者信息

Pechacek Joseph, Schmitt Monica M, Ferrè Elise M N, Webb Taura, Goldberg Joel, Pathan Sabina, Banerjee Camellia, Barber Princess, DiMaggio Thomas, Quinn Anne, Matkovits Theresa, Castelo-Soccio Leslie, Nussenblatt Veronique, Lionakis Michail S

机构信息

Fungal Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Intramural Clinical Management and Operations Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Open Forum Infect Dis. 2024 Jul 18;11(8):ofae428. doi: 10.1093/ofid/ofae428. eCollection 2024 Aug.

DOI:10.1093/ofid/ofae428
PMID:39091644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11292040/
Abstract

is a rare cause of cutaneous and systemic infection that requires long treatment courses with potentially toxic medications. We describe a patient with cutaneous protothecosis refractory to triazole monotherapy who experienced clinical and radiographic improvement with the novel oral lipid nanocrystal formulation of amphotericin B without experiencing toxicity.

摘要

是一种罕见的皮肤和全身感染病因，需要使用具有潜在毒性的药物进行长期治疗。我们描述了一名对三唑类单药治疗难治的皮肤原壁菌病患者，该患者使用新型口服两性霉素B脂质纳米晶制剂后临床和影像学均有改善，且未出现毒性反应。