Marino Francesca, Wang Dan, Merrihew Gennifer E, MacCoss Michael J, Dubal Dena B
Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Neurosciences Graduate Program, University of California, San Francisco, CA, US.
bioRxiv. 2024 Jul 26:2024.07.26.605328. doi: 10.1101/2024.07.26.605328.
Women show resilience to cognitive aging, in the absence of dementia, in many populations. To dissect sex differences, we utilized the FCG and XY* mouse models. Female gonads and sex chromosomes improved cognition in aging mice of both sexes. Further, presence of a second X in male and female mice conferred cognitive resilience while its absence in females blocked it. In the hippocampal proteome of aging female mice, the second X increased proteins involved in synaptogenesis signaling - a potential pathway to improved cognition.
在许多人群中，女性在没有痴呆症的情况下对认知衰老表现出韧性。为了剖析性别差异，我们使用了FCG和XY*小鼠模型。雌性性腺和性染色体改善了两性衰老小鼠的认知能力。此外，雄性和雌性小鼠中第二条X染色体的存在赋予了认知韧性，而雌性小鼠中第二条X染色体的缺失则阻断了这种韧性。在衰老雌性小鼠的海马蛋白质组中，第二条X染色体增加了参与突触形成信号传导的蛋白质——这是一条改善认知的潜在途径。
