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老年股骨转子间骨折患者术后严重并发症的危险因素及列线图预测模型

Risk factors and nomogram predictive model of severe postoperative complications in elderly patients with intertrochanteric fractures.

作者信息

Xu Ping, Xu Yanqiu

机构信息

Ping Xu, Department of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 39 Xiashatang, Suzhou, Jiangsu Province 215000, P.R. China.

Yanqiu Xu, Department of Surgery, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 39 Xiashatang, Suzhou, Jiangsu Province 215000, P.R. China.

出版信息

Pak J Med Sci. 2024 Aug;40(7):1566-1571. doi: 10.12669/pjms.40.7.9242.

Abstract

OBJECTIVE

To analyze risk factors of severe postoperative complications in elderly patients with intertrochanteric fractures (ITF), and to construct a predictive model.

METHODS

The medical records of 316 elderly patients with ITF who underwent surgical treatment in Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2020 to December 2022 were retrospectively analyzed. Univariate and multivariate logistic regression analyses were performed to identify risk factors of severe postoperative complications. A nomogram prediction model was constructed using the RMS package of R4.1.2 software. Accuracy and stability of the model was assessed using the receiver operating characteristic (ROC) curve, Hosmer-Lemeshow goodness-of-fit test, and decision curve analysis.

RESULTS

Age, American Society of Anesthesiologists (ASA) grading, combined medical diseases, preoperative bedridden condition, frailty, and preoperative albumin levels were all risk factors for severe postoperative complications in ITF patients were noted. These factors were then used to build a risk prediction model that had an area under the ROC curve (AUC) of 0.899 (95% confidence interval (: 0.846-0.951). The internal validation results of the Bootstrap method showed that the C-index value of the model was 0.899, and the calibration curve had a good fit with the ideal curve.

CONCLUSIONS

Age, ASA grading, combined medical diseases, preoperative bedridden condition, frailty, and preoperative albumin levels were independent risk factors for severe postoperative complications in elderly ITF patients. The constructed prediction model based on the above risk factors has a high predictive value.

摘要

目的

分析老年股骨粗隆间骨折(ITF)患者术后严重并发症的危险因素,并构建预测模型。

方法

回顾性分析2020年1月至2022年12月在苏州市中西医结合医院接受手术治疗的316例老年ITF患者的病历。进行单因素和多因素逻辑回归分析以确定术后严重并发症的危险因素。使用R4.1.2软件的RMS包构建列线图预测模型。使用受试者工作特征(ROC)曲线、Hosmer-Lemeshow拟合优度检验和决策曲线分析评估模型的准确性和稳定性。

结果

年龄、美国麻醉医师协会(ASA)分级、合并内科疾病、术前卧床情况、衰弱和术前白蛋白水平均为ITF患者术后严重并发症的危险因素。然后利用这些因素建立了一个风险预测模型,其ROC曲线下面积(AUC)为0.899(95%置信区间:0.846-0.951)。Bootstrap法的内部验证结果显示,模型的C指数值为0.899,校准曲线与理想曲线拟合良好。

结论

年龄、ASA分级、合并内科疾病、术前卧床情况、衰弱和术前白蛋白水平是老年ITF患者术后严重并发症的独立危险因素。基于上述危险因素构建的预测模型具有较高的预测价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/475f/11255789/41c87830e675/PJMS-40-1566-g001.jpg

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