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老年髋部骨折患者术后并发症预测模型的建立及经济负担分析

Development of a prediction model for postoperative complications and economic burden analysis in older patients with hip fractures.

作者信息

Shi Haoning, Gao Ying, Zhao Wanying, Wang Hongyu, Wu Xueqian, Wang Fei, Yang Xiao, Li Jing

机构信息

School of Nursing, Weifang Medical University, Weifang 261053, Shandong Province, PR China.

Linyi People's Hospital, Linyi 276034, Shandong Province, PR China.

出版信息

Heliyon. 2023 Sep 20;9(10):e20342. doi: 10.1016/j.heliyon.2023.e20342. eCollection 2023 Oct.

Abstract

PURPOSE

The high rates of disability and mortality due to postoperative complications of hip fractures in the elderly, especially the oldest-old individuals, have become an increasingly serious global public health concern. This study aimed to establish a nomogram prediction model and analyze the economic burden to guide clinical decision-making and improve patient prognosis.

METHODS

Data of 514 patients aged over 80 years with hip fractures who received surgical treatment were retrospectively collected, and the patients were divided into training and validation cohorts. Independent risk factors for postoperative complications were identified based on logistic regression analysis, and a nomogram was constructed. The model was evaluated for its discrimination and consistency using receiver operating characteristic (ROC) curves and calibration curves, and for its clinical benefit using decision curve analysis (DCA). The economic burden was analyzed using propensity score matching (PSM).

RESULTS

The American Society of Anesthesiologists (ASA) classification ≥Ⅲ, anemia, male sex, diabetes mellitus, and the number of comorbidities were found to be independent risk factors for postoperative complications in oldest-old patients with hip fracture (all  < 0.05). The areas under the curve (AUC) of the nomogram prediction model for the training and validation cohorts were 0.743 and 0.767, respectively, indicating reliable discrimination. The calibration curves and DCA showed that the model has good consistency and high benefits. The direct economic burden of postoperative complications for the patients was US$1045.10.

CONCLUSIONS

The nomogram model can accurately quantify the risk of postoperative complications among oldest-old patients with hip fractures and guide clinical professionals to implement early and targeted preventive treatment for high-risk patients.

摘要

目的

老年人髋部骨折术后并发症导致的高致残率和高死亡率,尤其是最年长的老年人,已成为日益严重的全球公共卫生问题。本研究旨在建立列线图预测模型并分析经济负担,以指导临床决策并改善患者预后。

方法

回顾性收集514例80岁以上接受手术治疗的髋部骨折患者的数据,并将患者分为训练队列和验证队列。基于逻辑回归分析确定术后并发症的独立危险因素,并构建列线图。使用受试者工作特征(ROC)曲线和校准曲线评估模型的区分度和一致性,使用决策曲线分析(DCA)评估其临床效益。使用倾向评分匹配(PSM)分析经济负担。

结果

发现美国麻醉医师协会(ASA)分级≥Ⅲ、贫血、男性、糖尿病和合并症数量是最年长髋部骨折患者术后并发症的独立危险因素(均<0.05)。训练队列和验证队列的列线图预测模型的曲线下面积(AUC)分别为0.743和0.767,表明区分度可靠。校准曲线和DCA显示该模型具有良好的一致性和高效益。患者术后并发症的直接经济负担为1045.10美元。

结论

列线图模型可以准确量化最年长髋部骨折患者术后并发症的风险,并指导临床专业人员对高危患者实施早期和有针对性的预防性治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057d/10539933/a5c37b23da9e/gr1.jpg

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