Salman Amber, Khawaja Asma Sajjad, Baig Kashif, Zehra Uruj
Amber Salman, MPhil. Department of Anatomy, University of Health Sciences, Lahore, Pakistan.
Asma Khwaja, MBBS. Department of Anatomy, University of Health Sciences, Lahore, Pakistan.
Pak J Med Sci. 2024 Aug;40(7):1516-1522. doi: 10.12669/pjms.40.7.8762.
To compare the degenerative features of cartilaginous endplate with bony endplate in association with intervertebral degeneration in local population at radiographic, macroscopic and microscopic level in human motion segments.
This cross-sectional descriptive study examined 59 lumbar spine motion segments from adult male cadavers at the Department of Anatomy, University of Health Sciences, Lahore, between May and September, 2022. Radiographic assessment observed bony endplate (BEP) for the presence of sclerosis & osteophytes and degeneration scores from 1-8 were assigned. Macroscopic assessment was done to evaluate BEP, cartilaginous endplate (CEP) and IVD, and scores ranged from 1to 28 for BEP, 1-4 for CEP and 1-64 for IVD were assigned. Microscopic assessment revealed degeneration scores of CEP ranged from 1-42 and 1-30 for IVD. Segments with BEP defects were also identified on radiographs & macroscopy.
Significant correlations were observed between the total degeneration scores of BEP with IVD and CEP scores (r=0.88 and r=0.909, respectively, p<0.001). Similarly, the total degeneration scores of the CEP is also significantly correlated with total IVD (r=0.86, p<0.001). Additionally, the samples with BEP defects were having higher IVD degeneration scores (p<0.001).
This study, for the first time identifies that there exists a critical association of bony and cartilaginous endplate with intervertebral disc degeneration individually in the same tissue sections using multi-dimension assessment methods. Degeneration in any of the components of VEP is consonantly associated with IVD degeneration. The BEP & CEP, though, they are unique structures but are interlinked with each other structurally and functionally.
在人体运动节段的影像学、宏观和微观层面，比较软骨终板和骨终板与当地人群椎间盘退变相关的退变特征。
这项横断面描述性研究于2022年5月至9月期间，对拉合尔健康科学大学解剖学系成年男性尸体的59个腰椎运动节段进行了检查。影像学评估观察骨终板（BEP）是否存在硬化和骨赘，并给出1 - 8分的退变评分。进行宏观评估以评价BEP、软骨终板（CEP）和椎间盘（IVD），BEP的评分范围为1至28分，CEP为1 - 4分，IVD为1 - 64分。微观评估显示CEP的退变评分为1 - 42分，IVD为1 - 30分。在影像学和宏观检查中也识别出有BEP缺陷的节段。
观察到BEP的总退变评分与IVD和CEP评分之间存在显著相关性（分别为r = 0.88和r = 0.909，p < 0.001）。同样，CEP的总退变评分也与IVD总评分显著相关（r = 0.86，p < 0.001）。此外，有BEP缺陷的样本其IVD退变评分更高（p < 0.001）。
本研究首次使用多维度评估方法，在同一组织切片中分别确定了骨终板和软骨终板与椎间盘退变之间存在关键关联。VEP任何一个组成部分的退变都与IVD退变一致相关。虽然BEP和CEP是独特的结构，但它们在结构和功能上相互关联。
