急性心肌梗死住院患者中黏附分子（细胞间黏附分子-1和E-选择素）与ABO血型的关系

Relationship of adhesion molecules (ICAM-1 and E-selectin) with ABO blood groups in patients hospitalized with acute myocardial infarction.

作者信息

Iqbal Mohammad Perwaiz, Azam Iqbal, Yousuf Farzana Abubaker, Kazmi Khawar

机构信息

Mohammad Perwaiz Iqbal, Department of Life Sciences, University of Management and Technology, Lahore, Pakistan. Pakistan Academy of Sciences, Islamabad, Pakistan. Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

Iqbal Azam, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2024 Aug;40(7):1551-1555. doi: 10.12669/pjms.40.7.8978.

DOI:10.12669/pjms.40.7.8978

PMID:39092065

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11255794/

Abstract

OBJECTIVES

Adhesion molecules, sICAM-1 and sE-selectin appear to have a major role in the pathogenesis of coronary artery disease (CAD). The focus of this study was to investigate the relationship of sICAM-1 and sE-selectin with ABO blood groups in Pakistani patients hospitalized with acute myocardial infarction (AMI).

METHODS

In a case-control study, 116 patients of acute myocardial infarction (AMI) and 116 healthy controls (age range for both: 30 years to 70 years; both males and females) were randomly selected from the Aga Khan University and National Institute of Cardiovascular Diseases, Karachi with informed consent. The blood samples were obtained and analyzed for ABO blood groups and serum levels of sICAM-1 and sE-selectin using kit methods. Statistical tests including independent sample t-test and Two-way ANOVA were used to study the association of these adhesion molecules with blood groups in AMI patients and healthy controls. Duration of the study was from July 2021 to June 30, 2023.

RESULTS

Mean serum levels of sICAM-1 were significantly higher in AMI patients compared to healthy controls (342±159 mg/dl vs. 227±104 mg/dl; p-value<0.001). Similarly, serum levels of sE-selectin were also significantly higher in AMI patients compared to healthy controls (53.6±26.9 mg/dl vs. 40.7± mg/dl; p-value<0.001). Moreover, mean concentrations of sICAM-1 and sE-selectin for the interaction between subject type (cases and control) and blood groups were statistically significant (p-value = 0.007 and p-value = 0.035, respectively).

CONCLUSION

There is an association of adhesion molecules, sICAM-1 and sE-selectin with ABO blood groups in Pakistani patients hospitalized with AMI.

摘要

目的

黏附分子可溶性细胞间黏附分子-1（sICAM-1）和可溶性E选择素（sE-选择素）似乎在冠状动脉疾病（CAD）的发病机制中起主要作用。本研究的重点是调查巴基斯坦急性心肌梗死（AMI）住院患者中sICAM-1和sE-选择素与ABO血型的关系。

方法

在一项病例对照研究中，从卡拉奇的阿迦汗大学和国家心血管疾病研究所随机选取116例急性心肌梗死（AMI）患者和116名健康对照者（两者年龄范围均为30岁至70岁；包括男性和女性），并获得知情同意。采集血样，使用试剂盒方法分析ABO血型以及sICAM-1和sE-选择素的血清水平。采用独立样本t检验和双向方差分析等统计检验来研究这些黏附分子与AMI患者和健康对照者血型之间的关联。研究时间为2021年7月至2023年6月30日。

结果

与健康对照者相比，AMI患者的sICAM-1平均血清水平显著更高（342±159mg/dl对227±104mg/dl；p值<0.001）。同样，与健康对照者相比，AMI患者的sE-选择素血清水平也显著更高（53.6±26.9mg/dl对40.7±mg/dl；p值<0.001）。此外，受试者类型（病例和对照）与血型之间相互作用的sICAM-1和sE-选择素平均浓度具有统计学意义（p值分别为0.007和0.035）。