Rac Monika, Rac Michal, Krzystolik Andrzej, Safranow Krzysztof, Chlubek Dariusz, Dziedziejko Violetta
Department of Biochemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Biomolecules. 2024 Dec 27;15(1):22. doi: 10.3390/biom15010022.
Inflammation markers in the blood may indicate a higher risk of unstable atherosclerosis. Selectins, a group of transmembrane glycoproteins, contribute to inflammation by helping certain blood cells bind to the endothelium.
The study included 100 patients with stable early-onset coronary artery disease (CAD), 75 men (aged 50-54) and 25 women (aged 55-64). Tests performed included biochemical analysis, ultrasound, and Doppler imaging of arteries and peripheral vessels. A biochemical control group of 50 cases without CAD (74% men, average age 48 ± 3.20 years) was also studied.
Higher triglyceride levels were strongly linked to elevated plasma E-selectin levels. However, no significant relationship was found between plasma E-selectin levels and biochemical, clinical, radiographic, or echographic measures.
Plasma E-selectin levels are not a reliable marker for detecting atherosclerotic plaques or related problems in individuals with stable, well-managed CAD. While E-selectin levels can be measured in clinical labs using immunoassays, they cannot replace standard cardiological and vascular imaging tests for diagnosing cardiac or vascular conditions.
血液中的炎症标志物可能表明动脉粥样硬化不稳定的风险较高。选择素是一组跨膜糖蛋白，通过帮助某些血细胞与内皮细胞结合来促进炎症反应。
该研究纳入了100例稳定型早发冠状动脉疾病（CAD）患者，其中75名男性（年龄50 - 54岁）和25名女性（年龄55 - 64岁）。所进行的检测包括生化分析、超声以及动脉和外周血管的多普勒成像。还研究了一个由50例无CAD的病例组成的生化对照组（74%为男性，平均年龄48 ± 3.20岁）。
较高的甘油三酯水平与血浆E - 选择素水平升高密切相关。然而，在血浆E - 选择素水平与生化、临床、影像学或超声检查指标之间未发现显著关系。
血浆E - 选择素水平不是检测稳定型、病情控制良好的CAD患者动脉粥样硬化斑块或相关问题的可靠标志物。虽然可以在临床实验室使用免疫测定法测量E - 选择素水平，但它们不能替代用于诊断心脏或血管疾病的标准心脏病学和血管成像检查。
