School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Curr Pharm Des. 2024;30(35):2753-2764. doi: 10.2174/0113816128305190240718112945.
Microemulsion gel, as a promising transdermal nanoparticle delivery system, addresses the limitations of microemulsions and enhances their performance in drug delivery and release. This article aims to discuss the advantages of microemulsion gel, including improved drug bioavailability, reduced drug irritation, enhanced drug penetration and skin adhesion, and increased antimicrobial properties. It explores the methods for selecting microemulsion formulations and the general processes of microemulsion preparation, as well as commonly used oil phases, surfactants, and co-surfactants. Additionally, the biomedical applications of microemulsion gel in treating conditions, such as acne and psoriasis, are also discussed. Overall, this article elucidates the significant potential of microemulsion gel in topical drug delivery, providing insights into future development and clinical applications.
微乳液凝胶作为一种有前途的经皮纳米粒子传递系统，解决了微乳液的局限性，并提高了其在药物传递和释放方面的性能。本文旨在讨论微乳液凝胶的优点，包括提高药物生物利用度、减少药物刺激性、增强药物渗透和皮肤附着力以及增加抗菌性能。它探讨了选择微乳液配方的方法和微乳液制备的一般过程，以及常用的油相、表面活性剂和助表面活性剂。此外，还讨论了微乳液凝胶在治疗痤疮和银屑病等疾病方面的生物医学应用。总的来说，本文阐明了微乳液凝胶在局部药物传递中的重要潜力，为未来的发展和临床应用提供了思路。
